Overview

In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. This book includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, it is intended to serve as a glimpse into the future.

Full Product Details

Author:   Phillip H. Factor
Publisher:   Springer
Imprint:   Springer
Edition:   2001 ed.
Dimensions:   Width: 15.50cm , Height: 1.90cm , Length: 23.50cm
Weight:   1.340kg
ISBN:  

9780792372684

ISBN 10:   0792372689
Pages:   291
Publication Date:   31 January 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Rationale for the Use of Gene Therapy for Critical Illness.- 2 Gene Delivery in the ICU.- 3 Non-viral Based Gene Therapy for Pulmonary Disease.- 4 Gene Therapy for Acute Lung Injury.- 5 Gene Therapy for Preservation of Alveolar Endothelial and Epithelial Function.- 6 Gene Therapy for Fibroproliferative Phase ARDS.- 7 Gene Therapy for Asthma.- 8 Gene Therapy for Infectious Diseases.- 9 Gene Therapy for HIV and ABDS-Related Opportunistic Infections.- 10 Gene Therapy for Acute Kidney Diseases.- 11 Gene Therapy Strategies to Augment Contractile Function in Heart Failure.- 12 Gene Therapy for Cerebrovascular Disease and Central Nervous System Trauma.- 13 Gene Therapy for Applications for the Treatment of Acute Inflammatory Conditions.- 14 Facilitation of Organ Transplantation with Gene Therapy.- 15 Cardiac Angiogenesis and Gene Therapy: A Strategy for Myocardial Revascularization.

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