Overview

This book has been written in response to the many physicians and scien- tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

Full Product Details

Author:   Huard J. (Children's Hospital of Pittsburgh and the University of Pittsburgh, USA) ,  F.H. Fu
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
ISBN:  

9783764340711

ISBN 10:   3764340711
Pages:   288
Publication Date:   29 June 2000
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Replaced By:   9780817640712
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Gene therapy in orthopaedics, C. Lattermann, H. Fu; 2 the use of different viral vectors and strategies for gene transfer to the musculoskeletal system, J. Huard; 3 regional gene therapy for hard tissues, J.R. Lieberman; 4 potential applications for gene therapy to the treatment of spinal disorders, K. Nishida, J.D. Lang, S.D. Boden, L.G. Gilbertson, J.K. Suh, P.D. Robbins, C.H. Evans; 5 the development of appraoches based on gene therapy to improve muscle healing following injury, J. Menetrey, C. Kasemkijwattana, C.S. Day, P. Bosch, M.S. Moreland, F.H. Fu, J. Huard; 6 non-viral gene therapy application in the repair of osteochondrial articular defects, R.S. Goomer, D.A. Amiel; 7 the potential of gene therapy for osteogenesis imperfecta, C. Niyibizi, P.N. Smith, J. Greenberg; 8 the role of nitric oxide as a candidate molecule for gene therapy in sports injuries, S.A. Rodeo, K. Izawa; 9 stem cells and tissue engineering, H.E. Young; 10 tissue engineering of ligament healing, S. Woo, N. Watanabe, K.A. Hildebrand; 11 muscle based tissue engineering for orthopaedic applications, D.S. Musgrave, C.S. Day, P. Bosch, J. Menetrey, C. Kasemkijwattana, M.S. Moreland, F.H. Fu, J. Huard; 12 applications of tissue engineering in cartilage repair, J.K. Suh, F.H. Hu; 13 immune reaction following cell and gene therapy, J.P. Tremblay; 14 vectors for gene transfer to joints, P.D. Robbins, S.C. Ghivizzani, J.C. Glorioso, C.H. Evans; 15 the use of adeno-associated virus for the musculoskeletal system, X. Xiao, R. Pruchnic, J. Li, J. Huard.

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