Overview

Gene probes find a wide variety of uses in molecular biology, and are essential tools for genetic research. This volume describes some of their many applications, from the study of nucleic acids, through blotting techniques and gene targeting, to the analysis of human genetic mutations. A companion volume covers the preparation of these probes. The volumes aim to contribute to a growing field of research.

Full Product Details

Author:   B. D. Hames ,  S. J. Higgins (both at the Department of Biochemistry and Molecular Biology, University of Leeds)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   162
Dimensions:   Width: 15.60cm , Height: 2.30cm , Length: 23.40cm
Weight:   0.687kg
ISBN:  

9780199634149

ISBN 10:   0199634149
Pages:   446
Publication Date:   23 November 1995
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

1: Hybridization strategy 2: Screening recombinant DNA libraries by hybridization and amplification 3: Screening human recombinant libraries with nucleic acid probes 4: Antibody screening of bacterial expression systems 5: Isolation of cDNA clones by direct expression in mammalian cells 6: Genomic mapping and gene structure analysis 7: Analysis of gene expression by blotting techniques 8: In situ hybridization of nucleic acid probes to cellular RNA 9: Applications of chromosomal in situ hybridization 10: Analysis of gene expression analysis by PCR: a quantitative approach 11: Analysis of protein expression by immunocytochemistry 12: Gene targeting in mammalian cells 13: Directed mutagenesis and mutant analysis 14: Human gene mutational analysis Appendix 1 Appendix 2

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