Overview

Margaret Shupnik and a team of leading investigators review the most recent breakthroughs in molecular endocrinology, emphasizing how studies of natural mutations and gene knockouts have illuminated endocrine processes. Using both animal and human model data, these authoritative researchers examine in depth the molecular basis of development, growth, and reproductive processes, the specific mutations that explain certain genetic syndromes, the hormonal regulation of gene expression (which affects the treatment of infertility and steroid-dependent cancers), and current research directions. Comprehensive and up-to-date, Gene Engineering in Endocrinology offers today's experimental and clinical endocrinologists, as well as reproductive biologists, a richly informative survey of what has already been accomplished with the genetic engineering of hormone processes and hormone-related genetic syndromes - research that promises powerful new experimental and therapeutic opportunities as this field continues its rapid development.

Full Product Details

Author:   Margaret A. Shupnik
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2000 ed.
Volume:   22
Dimensions:   Width: 17.80cm , Height: 2.50cm , Length: 25.40cm
Weight:   2.370kg
ISBN:  

9780896037182

ISBN 10:   0896037185
Pages:   428
Publication Date:   01 April 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I Growth, Development, and Metabolism.- 1 Differential Cell Signaling and Gene Activation by the Human Growth Hormone Receptor: From Cell Surface to Cell Nucleus.- 2 Insulin Action: Molecular Mechanisms and Determinants of Specificity.- 3 Ets Transcription Factors: Nuclear Integrators of Signaling Pathways Regulating Endocrine Gene Expression and Carcinogenesis.- 4 Pit-1 Expression, Regulation, and Modulation of Multiple Pituitary Genes.- 5 Subnuclear Trafficking of Glucocorticoid Receptors: General Mechanisms and Specific Recruitment to a Unique Target Site by Tethering to a DNA-Bound POU Domain Protein.- 6 Thyroid Hormone Receptors and Their Multiple Transcriptional Roles.- 7 Models of Resistance to Thyroid Hormone.- 8 Thyroid Hormone Receptor Family Members: Homodimers, Heterodimers, and Mechanisms of Transcriptional Repression.- 9 SF-1 and DAX-1: A Dynamic Duo in Endocrine Development.- II Reproductive System.- 10 Gene Knockout Models to Study the Hypothalamus-Pituitary-Gonadal Axis.- 11 Transgenic Approaches to Study Developmental Expression and Regulation of the Gonadotropin Genes.- 12 Molecular Events Defining Follicular Developments and Steroidogenesis in the Ovary.- 13 Regulation of Inhibin Subunit Gene Expression by Gonadotropins and cAMP in Ovarian Granulosa Cells.- 14 Placental Trophoblast Cells: Transcriptional Regulation and Differentiation.- 15 Alternative Splicing of mRNAs for cAMP-Responsive Transcriptional Factors and Modulation of Gene Transcription in the Testis.- 16 The Androgen Receptor, Androgen Insensitivity, and Prostate Cancer.- 17 Genetic Determination of Androgen Responsiveness.- 18 Steroid Receptor Regulation by Phosphorylation and Cell Signaling Pathways.- 19 Steroid Receptor Actions: Agonists and Antagonists and the Role of Coactivators and Corepressors.

Reviews

The editor should be congratulated on bringing together some of the most respected researchers in this area to write state-of-the-art papers in the area of molecular endocrinology... Graduate students and fellows interested in basic endocrinology would find this book a worthwhile investment with good diagrams and well-written summaries of some of the more confusing areas of this field...I love the book and will keep it handy when I sit down and decipher the new papers in molecular biology. -Doody's Health Science Book Review Journal

The editor should be congratulated on bringing together some of the most respected researchers in this area to write state-of-the-art papers in the area of molecular endocrinology... Graduate students and fellows interested in basic endocrinology would find this book a worthwhile investment with good diagrams and well-written summaries of some of the more confusing areas of this field...I love the book and will keep it handy when I sit down and decipher the new papers in molecular biology. - Doody's Health Science Book Review Journal

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