Overview
Since the 1990s, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. This text is divided into three sections: epithelial restitution; mucosal repair and ulcer healing; and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focusing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signalling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this text is a guide for investigators working in the field.
Full Product Details
Author: C.-H. Cho , J.-Y. Wang , G. Rogler , R. H. Hunt
Publisher: S Karger AG
Imprint: S Karger AG
Volume: 25
Weight: 0.670kg
ISBN: 9783805573825
ISBN 10: 3805573820
Pages: 252
Publication Date: 07 May 2002
Audience:
College/higher education
,
Professional and scholarly
,
Undergraduate
,
Postgraduate, Research & Scholarly
Format: Hardback
Publisher's Status: Active
Availability: In Print 
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Table of Contents
Part 1 Epithelial Restitution: Roles of Extracellular Matrix and Cytoskeleton in Intestinal Epithelial Restitution, J.R. Turner, M.D. Basson; Cytokines in Restitution, J. Yoo, M.M. Lotz, J.B. Matthews; Ca2+ Signalling in Epithelial Restitution, J.N. Rao, J.-Y. Wang; Polyamines in Intestinal Epithelial Restitution, S.A. McCormack, R.M. Ray, L.R. Johnson; Epithelial Restitution and Physical Stress, T. Osada, S. Watanabe, N. Sato; The Diacylglycerol/Protein Kinase C Pathway in Gastrointestinal Mucosal Injury and Defence: T.A. Miller, M.J. Redlak, L.M. Coy, M.M. Taher. Part 2 Mucosal Repair and Ulcer-Healing: Expression of Early Primary Response Genes in Healing of Gastrointestinal Mucosal Injury, J.-Y. Wang; Role of Angiogenesis and Angiogenic Growth Factors in Mucosal Repair and Ulcer Healing, A.S. Tarnawski, M.K. Jones, D. Bataar, R. Pai; Role of Platelets in Gastric Ulcer Healing - A Delivery System for Growth Factors, L. Ma, J.L. Wallace; Intestinal Mucosal Function following Ischemia/Reperfusion, P. Tso, A. Wollin; Helicobacter pylori Infection and Gastroduodenal Mucosal Damage and Healing, H.H.X. Xia, B.C.Y. Wong, S.K. Lam. Part 3 Experimental Therapeutics: Nitric Oxide-Releasing Agents - A New Generation of Drugs for Gastrointestinal Diseases, T. Brzozowski, P.C. Konturek, S.J. Konturek; Cyclooxygenase Inhibitor, a Foe or a Friend in the Mucosal Protection and Repair, B.M. Peskar, Polysaccharides - A New Role in Gastrointestinal Protection, C.C.M. Cho, E.S.L. Liu, V.Y. Shin, C.H. Cho; Modulators of Inducible Nitric Oxide Synthase - Potential Drugs for the Therapy of Gut Inflammation?, B.J.R. Whittle, M. Cavicchi, D. Lamarque; Peptide and Gene Therapy with Angiogenic Growth Factors bFGF, PDGF or VEGF in Gastrointestinal Ulcers in Rats, T. Khomenko, X. Deng, H. Ishikawa, Z. Sandor, S. Szabo; Gastrointestinal Protective Action of Prostaglandin E2 and EP Receptor Subtypes, K. Takeuchi, S. Kato, A. Tanaka.
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