Overview

The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predominantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overwiew of the pathologic and pathobiochemical principles of gallstone formation and the consequences for clinical therapeutic regimens. New therapeutic applications of HMG-CoA-reductase inhibitors and nonsteroidal anti-inflammatory drugs are also critically reviewed. Finally, for the interested reader an evaluation of prophylactic treatment against stone recurrence after successful conservative treatment and an appraisal of alternative management strategies supplement the information on the conservative treatment of gallstones.

Full Product Details

Author:   Werner Swobodnik ,  Roger D. Soloway ,  Hans Ditschuneit
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   0.490kg
ISBN:  

9783540509653

ISBN 10:   3540509658
Pages:   254
Publication Date:   23 February 1990
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Pathobiochemistry and Pathophysiology of Gallstone Development: Importance for Clinical Decision Processses.- Increased Biliary Lithogenicity Through Cholesterol Supersaturation.- Nucleation and Aggregation of Cholesterol Crystals in the Early Phase of Gallstone Genesis.- Modulation of the Edge Tension of Lipid Membranes by Cholate and Cholesterol and the Micelle-Vesicle Transition in Model Bile Systems.- Pigment Gallstones and Secondary Calcification of Gallstones.- The Influence of the Gallbladder Epithelium on Gallstone Formation.- Biliary Proteins and Their Role as Nucleating Inhibitors/Promotors.- Neurohormonal Aspects of Gallbladder Contractility in Gallstone Disease: The Role of Cholecystokinin.- Environmental Factors and Gallstones.- Different Therapeutic Approaches to Gallstone Disease.- Is Therapeutic Intervention Necessary in Gallstone Disease? The Surgeon’s Point of View.- Surgical Therapy for Acute Gallstone Complications.- Therapeutic Interventions in Patients with Gallbladder Stones: The Internist’s View.- Acute Biliary Pancreatitis.- Systemic Litholysis with Bile Acids.- Principles of Gallstone Dissolution with Chenodeoxycholic Acid, Ursodeoxycholic Acid, and the Combination of Both Bile Acids.- Systemic Litholysis with Bile Acids: Ursodeoxycholic Acid.- Combination Therapy of Chenodeoxycholic Acid and Ursodeoxycholic Acid.- Results of an Index-Controlled Combination Therapy with Ursodeoxycholic and Chenodeoxycholic Acid.- Extracorporeal Schock-Wave-Lithotripsy.- Physical Basis of Lithotriptors.- Extracorporeal Shock-Wave Lithotripsy of Gallstones.- Administration of Second-Generation Extracorporeal Shock Waves without Waterbath for Fragmentation of Extra- and Intrahepatic Bile Duct Stones.- Piezoelectric Lithotripsy of Gallbladder Stones.- BiliaryShock-Wave Lithotripsy: Experience of the First 3 Years in 612 Patients.- Laser Lithotripsy.- Laser Lithotripsy: Basic Physics.- Laser Lithotripsy: Clinical Applications.- Local Litholysis.- Local Litholytic Agents: Dissolution of Cholesterol Biliary Tract Stones with Methyl tert-Butyl Ether.- Local Litholysis of Calcified Pigment Stones.- Local Litholysis of Intrahepatic Calculi.- New Therapeutic Trends.- Reduction of Biliary Cholesterol Saturation by Inhibition of Cholesterol Synthesis: New Therapeutic Consequences?.- Gallstone Prevention by Alteration of Gallbladder Mucin Secretion via Prostaglandin Synthesis Inhibition.- Gallstone Prevention After Successful Treatment.- Intermittent Bile Acid Therapy as an Alternative Therapeutic Strategy.

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