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Author:   Giancarlo Colombo
Publisher:   Springer International Publishing AG
Imprint:   Humana
Edition:   Second Edition 2024
ISBN:  

9783031671500

ISBN 10:   3031671503
Pages:   341
Publication Date:   19 September 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Section 1: Molecular Biology, Biochemistry, and Functioning of the GABAB Receptor.- GABAB Receptor: Molecular Organization, Function, and Alternative Drug Development by Targeting Protein-Protein Interactions.- GABAB Receptor Functioning: Focus on Allosteric Modulation.- Section 2: Pharmacology of Baclofen.- Historical Overview on Baclofen, the Only GABAB Receptor Agonist Approved and Available for Clinical Use.- Baclofen for the Treatment of Spasticity and Dystonia in Cerebral Palsy.- Baclofen for the Treatment of Cough.- Baclofen for the Treatment of Alcohol Use Disorder.- Baclofen Safety, Toxicity, Withdrawal, and Overdose.- Section 3: Chemistry and Pharmacology of Positive Allosteric Modulators.- Recent Advances on Chemistry of GABAB Receptor Allosteric Modulators.- GABAB Receptor Positive Allosteric Modulators: Novel Approaches for Drug Design and Discovery.- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Neuropsychiatric Disorders.- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Substance Use Disorder and Food Addiction.- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Alcohol Use Disorder.- Section 4: Miscellanea.- γ-Hydroxybutiric Acid: A GABAB/GHB Receptor Agonist with a Unique Neuropharmacological and Therapeutic Profile.- Naturally Occurring GABAB Receptor Ligands.- Norman G. Bowery: A Founding Father of the GABAB Receptor Research Field – Reflections on His Contribution.

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Author Information

Giancarlo Colombo is a researcher at the Neuroscience Institute, National Research Council of Italy, Cagliari, Italy. His research interest is primarily on neurobiology and pharmacology of alcohol use disorder, with focus on the role of GABAB receptor in the control of multiple alcohol-related behaviors and development of GABAB receptor ligands as possible pharmacotherapies for alcohol use disorder. He has published approximately 240 papers in peer-reviewed journals and about 20 book chapters; he was also the editor of the 2016 volume on GABAB receptor. He serves as co-chief-editor of the journal Alcohol and Alcoholism.

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