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Author:   Arun K. Shukla (Indian Institute of Technology, Kanpur, India)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Volume:   132
Dimensions:   Width: 19.10cm , Height: 3.00cm , Length: 23.50cm
Weight:   1.250kg
ISBN:  

9780128035955

ISBN 10:   0128035951
Pages:   502
Publication Date:   11 March 2016
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Replaced By:   9780128133194
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Section 1 Trafficking, Localization and Imaging of GPCRs 1. Localization and Signaling of GPCRs in Lipid Rafts Van Anthony M. Villar, Santiago G. Cuevas, Xiaoxu Zheng, Pedro A. Jose 2. Imaging GPCRs Trafficking and Signaling with Total Internal Reflection Fluorescence Microscopy in Cultured Neurons Francheska Delgado-Peraza, Carlos Nogueras-Ortiz,  Agnes M. Acevedo Canabal, Cristina Roman-Vendrell, Guillermo A. Yudowski 3. Trafficking of Ciliary G-Protein Coupled Receptors Jeremy McIntyre, Mellisa M. Hege, Nicolas F. Berbari 4. Single Molecule Resolution of G Protein-Coupled Receptor (GPCR) Complexes Kim C Jonas, Ilpo Huhtaniemi, Aylin C Hanyaloglu 5. Quantification of the mRNA Expression of G-protein Coupled Receptors in Human Adipose Tissue Stefan Amisten Section 2 Signaling and Regulation of GPCRs 6. Studying the Regulation of Endosomal cAMP Production in GPCR Signaling Alexandre Gidon, Timothy N. Feinstein, Kunhong Xiao, Jean-Pierre Vilardaga 7. GPCR-Radioligand Binding Assays Colleen A. Flanagan 8. Assessing Smoothened-Mediated Hedgehog Signaling in Zebrafish Teresa Casar Tena, Melanie Philipp 9. GPCRs and Actin-Cytoskeleton Dynamics Genaro Vázquez-Victorio, Claudia González-Espinosa, Zyanya P. Espinosa-Riquer, Marina Macías-Silva Section 3 Cellular Assays for GPCRs 10. Olfactory Receptor Signaling Gabriela Antunes, Fabio Marques Simoes de Souza 11. Tracking GPCR Biosynthesis and Degradation Using a Non-Radioactive Pulse Chase Methodology Richard B. Vallee Richard Wargachuk, Dominic Devost, Cynthia Zhou, Terence E. Hébert 12. Tango Assay for Ligand Induced GPCR - ß-arrestin2 Interaction: Application in Drug Discovery Shalini Dogra, Chandan Sona, Ajeet Kumar, Prem N Yadav 13. Resonance Energy Transfer-Based Approaches to Study GPCRs  Mohammed Akli Ayoub 14. Quantitative Analysis of G Protein-Coupled Receptor Internalization Using DnaE Intein-Based Assay Bin Lu, Linjie Chen, Yaping Zhang, Ying Shi, Naiming Zhou 15. Cellular and Subcellular Context Determine Outputs from Signalling Biosensors Dominic Devost, Nicolas Audet, Cynthia Zhou, Hiroyuki Kobayashi, Hélène Bonin, Viktorya Lukashova, Christian Le Gouill, Michel Bouvier, Terence E. Hébert Section 4 Structural and Computational Investigation of GPCRs 16. Protease-Activated Receptors PARs in Cancer: Novel Biased Signaling and Targets for Therapy Bar-Shavit R, Maoz M, Kancharla A, Jaber M, Agranovich D, Grisaru-Granovsky S, Uziely B 17. Computational Methods for Studying G Protein-Coupled Receptors (GPCRs) Agnieszka A. Kaczor, Ewelina Rutkowska, Damian Bartuzi, Katarzyna M. Targowska-Duda, Dariusz Matosiuk, Jana Selent 18. Comparing Class A GPCRs to Bitter Taste Receptors: Structural Motifs, Ligand Interactions and Agonist-to-Antagonist Ratios Antonella Di Pizio, Anat Levit, Michal Slutzki, Maik Behrens, Rafik Karaman, Masha Y Niv 19. What Can Simulations Tell Us About GPCRs: Integrating the Scales Durba Sengupta, Manali Joshi, Chaitanya A. Athale, Amitabha Chattopadhyay

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Author Information

Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla’s research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.

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