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Author:   Marta Filizola
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   796
Dimensions:   Width: 17.80cm , Height: 1.30cm , Length: 25.40cm
Weight:   4.511kg
ISBN:  

9789402402582

ISBN 10:   9402402586
Pages:   228
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface. Section I Progress in Structural Modeling of GPCRs.- The GPCR Crystallography Boom: Providing an Invaluable Source of Structural Information and Expanding the Scope of Homology Modeling.- Modeling of G Protein-Coupled Receptors Using Crystal Structures: From Monomers to Signaling Complexes. Section II. GPCRs in Motion: Insights from Simulations.- Structure and Dynamics of G Protein-Coupled Receptors.- How the Dynamic Properties and Functional Mechanisms of GPCRs are Modulated by their Coupling to the Membrane Environment.- Coarse-Grained Molecular Dynamics Provides Insight into the Interactions of Lipids and Cholesterol with Rhodopsin.- Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods. Section III. GPCR-Focused Rational Design and Mathematical Modeling.- From Three-Dimensional GPCR Structure to Rational Ligand Discovery.- Mathematical Modeling Of G Protein-Coupled Receptor Function: What Can We Learn From Empirical And Mechanistic Models? Section IV. Bioinformatics Tools and Resources for GPCRs.- GPCRs & Company: Databases and Servers for GPCRs and Interacting Partners.- Bioinformatics Tools for Predicting GPCR Gene Functions. Index.

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