Overview

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Full Product Details

Author:   Vsevolod V. Gurevich ,  Eugenia V. Gurevich ,  John J.G. Tesmer
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   1st ed. 2016
Dimensions:   Width: 17.80cm , Height: 2.10cm , Length: 25.40cm
Weight:   7.904kg
ISBN:  

9781493937967

ISBN 10:   1493937960
Pages:   329
Publication Date:   21 July 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery.- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7.- Visual G Protein-Coupled Receptor Kinases.- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily.- “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs.- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications.- Differential Regulation of IGF-1 and Insulin Signaling by GRKs.- Differential Control of Potassium Channel Activity by GRK2.- Critical Role of GRK2 in the Prevention of Chronic Pain.- Roles of GRK Dysfunction in Alzheimer’s Pathogenesis.- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases.- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation.- GRK Roles in C. elegans.- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.

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