Overview

Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents, and many more. This book focuses on nomenclature, structural chemistry, and chemical and physical properties, along with various approaches for their synthesis. It is ideal for researchers in organic chemistry, both in academic and industrial settings and for postgraduates in chemistry and medicinal chemistry.

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9780128245316

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Raj Kumar Ph.D. is a Professor of Organic Medicinal Chemistry at Central University of Punjab, Bathinda, India 151001. He obtained his Ph.D. in Medicinal Chemistry (2007) from NIPER, Mohali, India and completed his postdoctoral fellowship (2007-2008) at the University of Maryland Baltimore County (UMBC), Maryland where he coinvented a fused heterocycle RK-33 (Raj Kumar-33) molecule for the treatment of Lung Cancer. His research interests focus on the design and synthesis of novel fused heterocycles of biological importance.

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