Overview

Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the ""personality"" of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses. Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book. This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.

Full Product Details

Author:   Christopher D. Richardson (Dalhousie University, Canada) ,  Nicholas H. Acheson (McGill University, Canada)
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Edition:   3rd edition
Dimensions:   Width: 20.60cm , Height: 3.80cm , Length: 27.20cm
Weight:   1.724kg
ISBN:  

9781119885863

ISBN 10:   1119885868
Pages:   672
Publication Date:   26 May 2025
Audience:   College/higher education ,  Tertiary & Higher Education
Format:   Paperback
Publisher's Status:   Active
Availability:   Available To Order  
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Table of Contents

Section I: Introduction To Virology 1. Introduction to Virology 2 Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie University 2. Virus Structure and Assembly 19 Stephen C. Harrison, Harvard University 3. Virus Classification: The World of Viruses 32 Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie University 4. Virus Entry 47 Ari Helenius, Swiss Federal Institute of Technology, Zurich Section II: Viruses of Bacteria And Archaea 5. Single- Stranded RNA Bacteriophages 60 Jan van Duin, University of Leiden Karthik Chamakura, Armata Pharmaceuticals, Inc., Los Angeles Ryland Young, Texas A&M University 6. Microviruses 74 Bentley A. Fane, University of Arizona Aaron P. Roznowski, University of Arizona 7. Bacteriophage T7 84 William C. Summers, Yale University Ian J. Molineux, University of Texas, Austin 8. Bacteriophage T4 94 Deborah M. Hinton, National Institutes of Health, Bethesda Eric S. Miller, North Carolina State University 9. Bacteriophage Lambda 110 Michael Feiss, University of Iowa 10. Viruses of Archaea 123 David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur, Paris Section III: Positive- Strand Rna Animal Viruses 11. Picornaviruses 140 Bert L. Semler, University of California, Irvine 12. Flaviviruses 152 Richard Kuhn, Purdue University Shelton Bradrick, Trudeau Institute, New York 13. Hepaciviruses 164 John Lok Man Law, Memorial University of Newfoundland Michael Houghton, University of Alberta 14. Togaviruses and Rubella Virus 178 Anil Kumar, University of Saskatchewan Milton Schlesinger, Washington University, St. Louis Sondra Schlesinger, Washington University, St. Louis Tom C. Hobman, University of Alberta 15. Coronaviruses 192 Marc Desforges, Ste. Justine Hospital, Université de Montréal Pierre Talbot, Institut Armand-Frappier Mark Denison, Vanderbilt University Section IV: Negative- Strand and Double- Stranded Rna Animal Viruses 16. Paramyxoviruses and Pneumoviruses 210 Nicholas H. Acheson, McGill University Daniel Kolakofsky, University of Geneva Laurent Roux, University of Geneva Christopher D. Richardson, Dalhousie University 17. Rhabdoviruses 226 Valery Grdzelishvili, University of North Carolina, Charlotte Cassandra A. Catacalos, University of North Carolina, Charlotte 18. Filoviruses 237 Heinz Feldmann, Rocky Mountain Laboratories, Montana Hans-Dieter Klenk, University of Marburg Nicholas H. Acheson, McGill University Angela Rasmussen, University of Saskatchewan 19. Bunyaviruses 251 Richard M. Elliott, University of Glasgow Lev Levanov, University of Helsinki Alexander Plyusnin, University of Helsinki 20. Influenza Viruses 262 Dalius J. Briedis, McGill University Alyson Kelvin, University of Calgary 21. Reoviruses 278 Kristen M. Ogden, Vanderbilt University Terence S. Dermody, University of Pittsburgh School of Medicine Section V: Small Dna Animal Viruses 22. Parvoviruses 292 Peter Beard, École Polytechnique Fédérale de Lausanne Sarah Wootton, University of Guelph 23. Polyomaviruses 302 Nicholas H. Acheson, McGill University James A. DeCaprio, Dana-Farber Cancer Institute, Harvard University 24. Papillomaviruses 318 Greg Matlashewski, McGill University Lawrence Banks, International Centre for Genetic Engineering and Biotechnology, Trieste Miranda Thomas, International Centre for Genetic Engineering and Biotechnology, Trieste Section VI: Large Dna Animal Viruses 25. Adenoviruses 330 Philip Branton, McGill University Richard C. Marcellus, McGill University Luca D. Bertzbach, Leibniz Institute of Virology, Hamburg Thomas Dobner, Leibniz Institute of Virology, Hamburg 26. Herpesviruses 344 Bernard Roizman, University of Chicago Gabriella Campadelli-Fiume, University of Bologna Richard Longnecker, Northwestern University Bruce Banfield, Queens University Craig McCormick, Dalhousie University 27. Poxviruses 366 Richard Condit, University of Florida Matthew D. Gresseth, Medical University of South Carolina Paula Traktman, Medical University of South Carolina Section VII: Viruses with a Reverse Transcriptase 28. Retroviruses 382 Alan Cochrane, University of Toronto 29. Human Immunodeficiency Virus 394 Alan Cochrane, University of Toronto 30. Hepadnaviruses 406 Christopher D. Richardson, Dalhousie University William Addison, University of Alberta D. Lorne Tyrrell, University of Alberta Section VIII: Viroids and Prions 31. Viroids and Hepatitis Delta Virus 420 Jean-Pierre Perreault, Université de Sherbrooke Martin Pelchat, University of Ottawa Charith Raj Adkar-Purushothama, Université de Sherbrooke 32. Prions 431 Dalius J. Briedis, McGill University David Westaway, University of California, San Francisco Section IX: Viruses of Plants, Algae, And Invertebrates 33. Cucumber Mosaic Virus 444 Marilyn J. Roossinck, Pennsylvania State College of Agricultural Sciences 34. Viruses of Algae and Mimivirus, a Giant Virus 457 Michael J. Allen, University of Exeter William H. Wilson, Marine Biological Association, Plymouth John A. Duffy, University of Exeter 35. Baculoviruses 478 Eric Carstens, Queens University Robert L. Harrison, U.S. Department of Agriculture, Beltsville, Maryland 36. Viruses of Invertebrates 489 Peter Krell, University of Guelph Section X: Host Defenses Against Virus Infection 37. Innate Immune Responses Against Virus Infection 506 Karen Mossman, McMaster University John Hiscott, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome Alessandra Zevini, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome 38. Adaptive Immune Responses to Virus Infection 527 Malcolm G. Baines, McGill University Karen Mossman, McMaster University Naglaa Shoukry, University of Montreal Section XI: Medical Applications of Virology 39. Antiviral Vaccines 542 Brian Ward, McGill University Hilary E. Hendin, McGill University 40. Antiviral Chemotherapy 562 Donald M. Coen, Harvard Medical School 41. Oncolytic Viruses 578 Vishnupriyan Kumar, Dalhousie University Liang-Tzung Lin, Taipei Medical University Shashi Gujar, Dalhousie University 42. Virus- Mediated Gene Therapy 586 Richard Peluso, Renovacor, Philadelphia Christopher D. Richardson, Dalhousie University

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Author Information

Christopher D. Richardson is Professor, Department of Microbiology & Immunology, Department of Pediatrics, Dalhousie University, Canada. Dr. Chris Richardson is a molecular virologist with 35 years of experience working with a variety of viruses. He earned his PhD at the University of British Columbia and did postdoctoral work at The Rockefeller University and the National Institutes of Health (Bethesda, USA). He previously held faculty positions at the National Research Council of Canada, McGill University, and the University of Toronto. Nicholas H. Acheson is Emeritus Professor of Microbiology & Immunology at McGill University, Quebec, Canada. He earned his PhD from The Rockefeller University and was a postdoctoral fellow at the Swiss Institute for Experimental Cancer Research (Lausanne) and Institut Pasteur (Paris). He carried out research on Semliki Forest virus and mouse polyomavirus, and taught a virology course for advanced undergraduate students at McGill University.

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