Overview
The clinical trial is ""the most definitive tool for evaluation of the applicability of clinical research."" It represents ""a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments"" [1]. It has been called on many occasions, ""the gold st- dard"" against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2-21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.
Full Product Details
Author: Lawrence M. Friedman ,
Curt D. Furberg ,
David L. DeMets
Publisher: Springer-Verlag New York Inc.
Imprint: Springer-Verlag New York Inc.
Edition: 4th ed. 2010
Dimensions:
Width: 15.50cm
, Height: 2.30cm
, Length: 23.50cm
Weight: 0.646kg
ISBN: 9781441915856
ISBN 10: 1441915850
Pages: 445
Publication Date: 21 September 2010
Audience:
College/higher education
,
Professional and scholarly
,
Postgraduate, Research & Scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Out of Print
Availability: Out of print, replaced by POD
We will order this item for you from a manufatured on demand supplier.
Reviews
From the reviews of the fourth edition: This book is clearly written for students in the arena of health care. Physicians and health care providers can use it as a reference book. The organization and structure is good and logical. it deepens the understanding of applications of statistical methods and the analysis of clinical trials. Also, it provides a list of references at the end of each chapter. In summary, this is an important contribution, providing up-to-date coverage on clinical trial methodology in a logical and systematic manner. (Technometrics, Vol. 53 (2), May, 2011)
From the reviews of the fourth edition: This book is clearly written for students in the arena of health care. Physicians and health care providers can use it as a reference book. ... The organization and structure is good and logical. ... it deepens the understanding of applications of statistical methods and the analysis of clinical trials. Also, it provides a list of references at the end of each chapter. ... In summary, this is an important contribution, providing up-to-date coverage on clinical trial methodology in a logical and systematic manner. (Technometrics, Vol. 53 (2), May, 2011)
