Overview

Provides concise, up-to-date articles highlighting the most recent advances in mechanisms of toxicology and the methods for studying them. Examines chemical approaches to the solution of toxicologically interesting problems. Originally published in Chemical Research in Toxicology, the articles convey the opportunity and excitement that exists at the interface of chemistry and toxicology. Twenty-one articles are grouped into four broad categories: Toxic Agents and their Actions; Enzymes of Activation, Inactivation, and Repair; Physical Methods; and Macromolecular Modification.

Full Product Details

Author:   Lawrence J. Marnett (Vanderbilt University)
Publisher:   American Chemical Society
Imprint:   American Chemical Society
Dimensions:   Width: 21.60cm , Height: 1.50cm , Length: 27.90cm
Weight:   0.700kg
ISBN:  

9780841224285

ISBN 10:   0841224285
Pages:   294
Publication Date:   01 January 1992
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   No Longer Our Product
Availability:   In Print  
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Table of Contents

Metabolic Activation of Valproic Acid and Drug-Mediated Hepatotoxicity. Role of the Terminal Olefin, 2-n-Propyl-4-pentenoic Acid ; Photochemistry of the Psoralens ; Mechanisms of 3-Methylindole Pneumotoxicity ; Redox Chemistry of Anthracycline Antitumor Drugs and Use of Captodative Radicals as Tools for its Elucidation and Control ; The Fecapentaenes, Potent Mutagens from Human Feces ; Mammalian Synthesis of Nitrite, Nitrate, Nitric Oxide, and N-Nitrosating Agents ; Mechanisms of Immunotoxicity to Isocyanates ; Mechanisms of Drug-Induced Lupus ; Molecular and Biochemical Mechanisms of Chemically Induced Nephrotoxicity: A Review ; Oxidation of Toxic and Carcinogenic Chemicals by Human Cytochrome P-450 Enzymes ; Glutathione S-Transferases: Reaction Mechanism, Structure, and Function ; Isolation and Purification of UDP-Glucuronosyltransferases ; DNA Repair ; Applications of NMR Spectroscopy to Studies of Reactive Intermediates and Their Interactions with Nucleic Acids ; Fluorescence Line Narrowing: A High-Resolution Window on DNA and Protein Damage from Chemical Carcinogens ; Site-Specifically Modified Oligodeoxynucleotides as Probes for the Structural and Biological Effects of DNA-Damaging Agents ; Sequence Selectivity of DNA Covalent Modification ; Covalent Bonding of the Prosthetic Heme to Protein: A Potential Mechanism for the Suicide Inactivation or Activation of Hemoproteins ; Biochemical, Structural, and Functional Properties of Oxidized Low-Density Lipoprotein ; Metallothionein and Other Cadmium-Binding Proteins: Recent Developments ; Loss of Cancer Suppressors, a Driving Force in Carcinogenesis

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