Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective
Author:   Clemens Sonntag
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Edition:   Softcover reprint of hardcover 1st ed. 2006
ISBN:  

9783642065545


Pages:   523
Publication Date:   12 February 2010
Format:   Paperback
Availability:   Out of print, replaced by POD   Availability explained
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Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective


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Overview

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.

Full Product Details

Author:   Clemens Sonntag
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of hardcover 1st ed. 2006
Dimensions:   Width: 15.50cm , Height: 2.70cm , Length: 23.50cm
Weight:   0.825kg
ISBN:  

9783642065545


ISBN 10:   3642065546
Pages:   523
Publication Date:   12 February 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD   Availability explained
We will order this item for you from a manufatured on demand supplier.

Table of Contents

Formation of Reactive Free Radicals in an Aqueous Environment.- The Hydroxyl Radical.- Hydrogen Atom and Hydrated Electron.- Inorganic Radicals.- Carbon-Centered Radicals.- Heteroatom-Centered Radicals.- Peroxyl Radicals.- Polymer Radicals.- Nucleobases, Nucleosides and Nucleotides.- Polynucleotides and Single-Stranded DNA Fragments.- DNA and Double-Stranded Oligonucleotides.- Methods.

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Author Information

Born in 1936, Chemistry at Heidelberg, Vienna and Karlsruhe, PhD (1964 with D. Schulte-Frohlinde) and Habilitation (1970) at Karlsruhe. Postdoc with F. S. Dainton (Leeds). 1960-1970 Nuclear Research Center Karlsruhe, 1970- 2001 Max-Planck-Institut für Strahlenchemie, Mülheim. After retirement continuing collaboration with the Leibniz-Institut für Oberflächenmodifizierung (IOM), Leipzig.

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