Free Fatty Acid Receptors
Author:   Graeme Milligan ,  Ikuo Kimura
Publisher:   Springer International Publishing AG
Edition:   1st ed. 2017
Volume:   236
ISBN:  

9783319506920


Pages:   256
Publication Date:   17 February 2017
Format:   Hardback
Availability:   Manufactured on demand   Availability explained
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Free Fatty Acid Receptors


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Overview

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Full Product Details

Author:   Graeme Milligan ,  Ikuo Kimura
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2017
Volume:   236
Dimensions:   Width: 15.50cm , Height: 2.10cm , Length: 23.50cm
Weight:   5.685kg
ISBN:  

9783319506920


ISBN 10:   3319506927
Pages:   256
Publication Date:   17 February 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Ligands at Free Fatty Acid Receptor 1 (GPR40).- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41.- Ligands at GPR84.- Ligands at Free Fatty Acid Receptor 4 (GPR120).- Homology modelling of FFA receptors.- Sensors for FFA receptors.- Key questions for translation of FFA receptors from pharmacology to medicines.- Polymorphic variation in FFA receptors. Functions and consequences.- The role and future of FFA1 as a therapeutic target.- Gut hormone regulation and secretion via FFA1 and FFA4.- The role of FFA2 and FFA3 in metabolic regulation.- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors.- Free Fatty Acid receptors and cancer. 

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