Overview

The metabolic products of micro-organisms can be classified either as compounds of primary metabolic concern or else as secondary metabolites - substances which are apparently non-essential to the producing or- ganism. Fungi have a remarkable capacity to produce such secondary metabolites, e. g. mycotoxins with a diverse array of structural and pharmacological properties (1). The present resurgence of interest in all aspects of mycotoxin research (2, 3) can be related to the impact of the hepatotoxins (aflatoxin, sporidesmin, and phomopsin), nephrotoxins (ochratoxin and citrinin), and dermal toxins (trichothecenes) on human and animal health. Some of the mycotoxins appear to act at the level of the central nervous system. Ergotism, the earliest known mycotoxicosis, that is a disease caused by mycotoxins, was attributed to the contamination of wheat by the parasitic neurotoxin-producing fungus, C/aviceps purpurea. These neuro- toxins elaborated by C. purpurea are collectively called the ergot toxins (4). The neurotoxin, citreoviridin (1) which causes paralysis in the extremities of laboratory animals, followed sometimes by convulsions and respiratory arrest, has been implicated in acute cardiac beri-beri in Japan (5). Tremoring has not been associated with citreoviridin or the structurally related aurovertins (2) (6) and asteltoxin (3) (7); these compounds are therefore excluded from this review. However, verrucosidin (4) (8), a tremorgenic compound which structurally resembles (1)-(3), will be described later.

Full Product Details

Author:   J.G. Buchanan ,  P. Crews ,  B. Epe ,  F.J. Evans
Publisher:   Springer Verlag GmbH
Imprint:   Springer Verlag GmbH
Edition:   Softcover reprint of the original 1st ed. 1983
Volume:   44
Dimensions:   Width: 15.20cm , Height: 1.80cm , Length: 22.90cm
Weight:   0.499kg
ISBN:  

9783709187166

ISBN 10:   3709187168
Pages:   328
Publication Date:   19 January 2012
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Pro-Inflammatory, Tumour-Promoting and Anti-Tumour Diterpenes of the Plant Families Euphorbiaceae and Thymelaeaceae.- I. Introduction.- II. Classification of Structural Types.- III. Botanical Considerations.- IV. Biosynthetic Relationships.- V. Isolation of Diterpenes.- VI. The Macrocyclic Diterpenes.- VII. Tigliane Diterpenes.- VIII. Ingenane Derivatives.- IX. Daphnane Derivatives.- X. Closing Remarks.- Acknowledgements.- References.- Bitter Principles of Cneoraceae.- I. Introduction.- II. Nomenclature and Classification.- III. Constitution and Configuration of Cneorins A, B, C and D.- IV. The Series of Stereoisomeric ?8(30)-Olefms.- V. Stereoisomeric Alcohols with an 8-OH Group and (5 S, 10 R)-Configuration.- VI. Cneorins and Tricoccins with a C-7 Carbonyl Group.- VII. C-7 Hemiacetals and Methylacetals with (5S, 10R, 17R)-Configuration.- VIII. C-9 Hemiacetals with (5S, 8S, 10R-Configuration.- IX. Cyclic Peroxides.- X. Bitter Principles with a ?-Lactol Ring (C-15 Hemiacetals).- XI. Tetranortriterpenoids from Cneoraceae.- XII. Protolimonoids.- XIII. Comments on Biosynthesis of Cneorins and Tricoccins.- XIV. Tables of Natural Bitter Principles from Cneoraceae.- References.- Chemical and Biological Aspects of Marine Monoterpenes.- I. Introduction.- II. Structural Variation.- III. The Role of Halogens in Biogenesis.- IV. Relationships Between Taxonomy and Occurrence of Structural Types.- V. Metabolite Transfer and Biological Activity.- VI. Spectroscopic and Chemical Properties.- VII. Physical and Spectroscopic Tables.- Acknowledgement.- References.- The C-Nucleoside Antibiotics.- I. Introduction.- II. General Aspects of C-Nucleosides.- III. Showdomycin.- IV. The Formycins.- V. Pyrazofurin (Pyrazomycin).- VI. Oxazinomycin (Minimycin).- VII. The Ezomycins.- VIII..Biosynthesis of C-Nucleoside Antibiotics.- References.- Author Index.

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