Overview

The discovery of functional MRI (fMRI) methodology in 1991 was a breakthrough in neuroscience research. This non-invasive, relatively high-speed, and high sensitivity method of mapping human brain activity enabled observation of subtle localized changes in blood flow associated with brain activity. Thousands of scientists around the world have not only embraced fMRI as a new and powerful method that complemented their ongoing studies but have also gone on to redirect their research around this revolutionary technique. This volume in the MIT Press Essential Knowledge series offers an accessible introduction to the history, fundamental concepts, challenges, and controversies of fMRI, written by one of the pioneers in the field. Peter Bandettini covers the essentials of fMRI, providing insight and perspective from his nearly three decades of research. He describes other brain imaging and assessment methods; the sources of fMRI contrasts; the basic methodology, from hardware to pulse sequences; brain activation experiment design strategies; and data and image processing. A unique, standalone chapter addresses major controversies in the field, outlining twenty-six challenges that have helped shape fMRI research. Finally, Bandettini lays out the four essential pillars of fMRI: technology, methodology, interpretation, and applications.

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Peter A. Bandettini is chief of the Section on Functional Imaging, director of the Functional MRI Facility, and director of the Center for Multimodality Neuroimaging at the National Institute of Mental Health of the National Institutes of Health. Chris Sorenson has worked extensively as an actor, playwright, and screenwriter. He studied at the Rutgers Professional Actor Training Program and is an original member of the Present Company, producers of FringeNYC. The Thin Air Theatre Company of Colorado considers him their playwright-at-large and have produced ten of his plays over the past eleven years. His screenplays The Roswell Project and Classic Rock are both currently in production, and his horror script Suckerville is currently in development. He has received three AudioFile Earphones Awards, and his recording of Sent by Margaret Peterson Haddix was selected by AudioFile as one of the Best Audiobooks of 2010.

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