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OverviewFull Product DetailsAuthor: Clemens Fritsch , Thomas RuzickaPublisher: Springer Verlag GmbH Imprint: Springer Verlag GmbH Edition: 2003 ed. Dimensions: Width: 21.50cm , Height: 1.30cm , Length: 28.40cm Weight: 0.700kg ISBN: 9783211838273ISBN 10: 3211838279 Pages: 128 Publication Date: 17 June 2003 Audience: Professional and scholarly , College/higher education , Professional & Vocational , Postgraduate, Research & Scholarly Format: Hardback Publisher's Status: Active Availability: Out of stock ![]() The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available. Table of ContentsIntroduction and Historical Landmarks * Definition of the Photodynamic Action * Optimum Photosensitizing Agent for Photodynamic Action * Definition of Fluorescence Detection with ALA- Induced Porphyrins (FDAP) * Mechanisms of Action in PDT d-Aminolevulinic Acid (ALA) * Chemistry of ALA and ALA Methylester (ALA) * Metabolism of ALA * Pharmacodynamics of ALA Light Used in FDAP and PDT Unresolved Issues ind FDAP and PDT Fluorescence Detection of ALA-induced Porphyrins (FDAP) * FDAP: Evaluation of the ALA-Induced Fluoresence in Skin Diseases Ex vivo - Investigations on ALA-induced Porphyrins * Porphyrin Accumulation in Cells (in vitro) * Porphyrin Accumulation in Skin Tumors, Colon and Bronchial Carcinomas after Administration of ALA (ex vivo) In vivo - Investigations on ALA-Induced Porphyrin/FDAP * FDAP: Kinetics of ALA-induced Porphyrins in Human Cutaneous Tumors, Psoriasis Lesions and Normal Skin * FDAP: Kinetics of PorphyrinAccumulation in Solar Keratoses: ALA versus ALA Methylester * FDAP: use of the in vivo - Fluorescence for Surgical Planning * FDAP: Evaluation of the Optimum Photosensitizing Substance or its Prodrug * FDAP: Evaluation of the Optimum Exciting Light Source * FDAP: Correlation of in vivo - Tumor Fluorescence and Histopathology * FDAP: Course of FDAP in Relation to the Number of PDT-Sessions The Clinical Use of FDAP * FDAP in Clinically Well-defined Tumors * FDAP in Clinically Ill-defined Lesions * FDAP in Pretreated or Damaged Skin * Limitations of FDAP * Usefulness of FDAP in Guiding Tumor Therapies Photodynamic Therapy in Cutaneous Diseases * PDT: Evaluation of the Efficacy in Solar Keratoses * PDT: Evaluation of the Efficacy in Bowen`s Disease * PDT: Evaluation of the Efficacy in Basal Cell Carcinoma * PDT: Evaluation of the Efficacy Sqamous Cell Carcinoma * PDT: Evaluation of the Efficacy in Psoriatric Lesions * PDT: Evaluation ofthe Efficacy in Selected Cutaneous Diseases * PDT in Skin Cancers and Precanceroses Others than Discussed Above * PDT in Tumors of the Oral Mucosa * PDT in Non-neoplastic Skin Diseases * PDT in Non-dermatological Indications * PDT: Evaluation of the Optimum Photosensitizing Substance or its Prodrug * PDT: Evaluation of the Optimum Exciting Light Source General Discussion * FDAP: Indications and Limits * PDT: Indications and Limits * Safety and Tolerability of ALA-PDT * Regulatory Affairs Concerning Aminolevulinic Acid * Regulatory Affairs Concerning Aminolevulinic Acid Methylester Conclusion SummaryReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |