Overview

The pioneering work of a few investigators in the 1960s made it clear that genetic factors play an important role in tumour development. Hereditary factors have nonetheless received far less attention than environmental ones in the study of the causes of cancer. This has resulted in the discrepancy that there is a strong general concern about cigarette smoking and alcohol abuse (the two most common causes of cancer in humans), yet that many physicians give little or no attention to the patient's familial history and that first-degree relatives of patients are rarely felt to be at risk because of the common genetic background. This volume focuses on the genetic features of most human tumours, emphasizing their familial and hereditary basis as well as the close interaction between environmental and genetic factors. The aim is to translate increased knowledge of familial cancer into new programmes for cancer prevention and detection, such as the surveillance of high-risk individuals.

Full Product Details

Author:   Maurizio Ponz de Leon
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Volume:   v. 136
Weight:   0.690kg
ISBN:  

9783540576334

ISBN 10:   3540576339
Pages:   349
Publication Date:   24 October 1994
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Genetic Aspects of Disease: Categories of Genetic Disorders.- Biomarkers of Increased Susceptibility to Cancer.- Oncogenes and Tumor Suppressor Genes.- Genetic Factors in Solid Tumors of Childhood.- Retinoblastoma.- Multiple Endocrine Neoplasia.- Hereditary Tumors of the Nervous System.- Hereditary Melanoma and Dysplastic Nevus Syndrome.- Hereditary and Familial Breast Tumors.- Hereditary and Familial Ovarian Cancer.- Genetic Factors in Lung Cancer.- Genetic Factors in Precancerous Lesions and Cancer of the Esophagus.- Genetic Predisposition and Environmental Factors in Gastric Carcinoma.- Hereditary and Familial Colorectal Cancer.- Hereditary Gastrointestinal Polyposis Syndromes.- Familial Aspects in Carcinoma of the Pancreas.- Li-Fraumeni Syndrome.- Genetic Factors in Leukemia and Lymphoma.- Familial Factors in Cancer of the Genitourinary Tract.- Cancer-Prone Hereditary Diseases Associated with Abnormalities of DNA Repair.- Familial Tumors of Other Organs.

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