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Author:   Kirsi Rilla
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
ISBN:  

9783031688133

ISBN 10:   3031688139
Pages:   296
Publication Date:   07 November 2025
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Chapter 1. Manipulating the Matrix: Role of Extracellular Vesicles.- Chapter 2. Extracellular Matrix Remodeling in Physiological and Pathological Conditions: Insight into Extracellular Vesicles Contribution.- Chapter 3. Extracellular Matrix Modulation by Cancer-Derived Extracellular Vesicles: Impact on Cancer Malignancy.- Chapter 4. Role of Hyaluronan in Interactions of Tumor-Derived Extracellular Vesicles with Cells of Monocyte Origin.- Chapter 5. Extracellular Vesicles in Inflammation.- Chapter 6. Extracellular Vesicles in Synovial Fluid: Their role in Joint Homeostasis and Patophysiology.- Chapter 7. Extracellular Vesicles from Obese Adipose Tissue and Their Relationship with the Development of Comorbidities.- Chapter 8. Potential of Extracellular Vesicles as Therapeutics in Retinal Diseases.- Chapter 9. AFM-Based Mechanobiology of Extracellular Vesicles.- Chapter 10. Bioaffinity Recognition of Extracellular Vesicle Glycosylations.- Chapter 11. Imaging of EVs in the 3D Matrix Networks.

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Author Information

Kirsi Rilla, PhD, is a group leader at the Institute of Biomedicine, University of Eastern Finland. She received her M.Sc. degree in cell biology from the University of Jyväskylä (1998). Her Ph.D. project in the Tammi research group was focused on intracellular trafficking of hyaluronan synthases and regulation of their activity (2006). The thesis work led to the discovery of hyaluronan-dependent filopodia that act as hyaluronan factories. Especially intriguing is her finding that those filopodia act as platforms for extracellular vesicle shedding. Dr Rilla is experienced on the cellular and molecular mechanisms of cancer, extracellular matrix, hyaluronan and the biology of extracellular vesicles. During her research career, she has specifically focused on modern in vitro imaging techniques. Her current project is focused on extracellular vesicles, mechanism contributing to regulation of their secretion, interaction and effects on target cells and utilization of EVs as specific carriers of therapy.  

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