Overview

An edited volume that looks at the state of psychiatric genetics and how to chart a path forward. An edited volume that looks at the state of psychiatric genetics and how to chart a path forward. In this edited collection, experts from psychiatric and statistical genetics, neurobiology, and clinical psychiatry investigate whether and how to pursue the discovery of additional genetic risk factors for mental illnesses. Using the existing knowledge and frameworks of genetic risk factors, they look at how a better understanding of the biology that underlies mental illnesses can improve and enhance the care that patients receive.

Full Product Details

Author:   Joshua A. Gordon ,  Elisabeth Binder
Publisher:   MIT Press Ltd
Imprint:   MIT Press
Volume:   31
Dimensions:   Width: 15.40cm , Height: 1.50cm , Length: 22.90cm
Weight:   0.448kg
ISBN:  

9780262547383

ISBN 10:   0262547384
Pages:   340
Publication Date:   10 October 2023
Audience:   General/trade ,  General
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
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Table of Contents

List of Contributors vii Preface xi 1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1 Gene Discovery  2 Delineating Additional Risk Factors 13 3 Data Collection: Next Steps in Psychiatric Genetics 39 4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51 Understanding Rare Variation  5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69 6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103 7 Experimental Model Systems for Rare and Common Variants 117 Understanding Common Variation 8 Common Alleles: Next Steps in the Study of Common Variants 131 9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155 10 From Common Variant to Function: State-of-the-Art Approaches 167 11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179 Clinical Considerations  12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201 13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219 14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237 15 Psychiatric Genetic Counseling: Next Steps 249 16 Concluding Summary 261 Bibliography 267 Subject Index 319 Strungmann Forum Report Series 325

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Author Information

Joshua A. Gordon is Director of the National Institute of Mental Health (NIMH) and Chief of the Integrative Neuroscience Section at the National Institute of Neurologic Disorders and Stroke (NINDS). Elisabeth B. Binder is a director and scientific member at the Max Planck Institute of Psychiatry.

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