Overview

This volume explores the latest methods that seek to address the vital questions being asked in neurotoxicology research. The chapters in this book cover a variety of available methods from the molecular level to the organism level, and both in vitro and in vivo approaches, including alternative model organisms. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Experimental Neurotoxicology Methods is a valuable resource for both young and experienced researchers who are looking for guidance to implement these methods in their laboratories or for understanding the data generated through these techniques.

Full Product Details

Author:   Jordi Llorens ,  Marta Barenys
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2021
Volume:   172
Weight:   0.964kg
ISBN:  

9781071616390

ISBN 10:   1071616390
Pages:   491
Publication Date:   25 July 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface to the Series… Preface… Table of Contents… Contributing Authors… Part I Cytological and Histological Evaluation in Rodents 1. Amino-Cupric-Silver (A-Cu-Ag) Staining to Detect Neuronal Degeneration in the Mouse Brain: The de Olmos Technique Rosario Moratalla, Adrián Sanz-Magro, and Noelia Granado 2. Assessment of Auditory Hair Cell Loss by Cytocochleograms Aurélie Thomas, Thomas Venet, and Benoît Pouyatos 3. Evaluation of Cellular and Molecular Pathology in the Rodent Vestibular Sensory Epithelia by Immunofluorescent Staining and Confocal Microscopy Alberto F. Maroto, Erin A. Greguske, Alejandro Barrallo-Gimeno, and Jordi Llorens 4. Morphometric Analysis of Axons and Dendrites as a Tool for Assessing Neurotoxicity Rhianna K. Morgan, Martin Schmuck, Ana Cristina Grodzki, Donald A. Bruun, Lauren E. Matelski, and Pamela J. Lein Part II Physiological Evaluation in Rodents 5. DPOAEs for the Assessment of Noise- or Toxicant-Induced Cochlear Damage in the Rat Thomas Venet, Aurélie Thomas, Ludivine Wathier, and Benoît Pouyatos 6. Use of Visual Evoked Potentials to Assess Deficits in Contrast Sensitivity in Rats following Neurotoxicant Exposures William K. Boyes 7. Electrophysiological Assessments in Peripheral Nerves and Spinal Cord in Rodent Models of Chemotherapy-Induced Painful Peripheral Neuropathy Susanna Park, Cynthia L. Renn, Justin G. Lees, Susan G. Dorsey, Guido Cavaletti, and Valentina A. Carozzi Part III Behavioral Evaluation in Rodents 8. The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities David V. Gauvin 9. Behavioral Assessment of Vestibular Dysfunction in Rats Alberto F. Maroto, Erin A. Greguske, Meritxell Deulofeu, Pere Boadas-Vaello, and Jordi Llorens 10. Assessment of Olfactory Toxicity in Dodents David C. Dorman and Melanie L. Foster 11. Assessment of Neurotoxicant-Induced Changes in Behavior: Issues Related to Interpretation of Outcomes and Experimental Design Deborah A. Cory-Slechta, Katherine Harvey, and Marissa Sobolewski Part IV Molecular Methods 12. Assessment of Neurofilament Light Protein as a Serum Biomarker in Rodent Models of Toxic-Induced Peripheral Neuropathy Giulia Fumagallia, Guido Cavalettia, Henrik Zetterberg, and Cristina Meregallia 13. Assessing Neurotoxicant-Induced Inflammation in the Central Nervous System: Cytokine mRNA with Immunostaining of Microglia Morphology Christopher A. McPherson and G. Jean Harry 14. Mitochondrial Stress Assay and Glycolytic Rate Assay in Microglia using Agilent Seahorse Extracellular Flux Analyzers  Gabrielle Childers and G. Jean Harry Part V Alternative Model Organism-Based Methods 15. Assessment of Larval Zebrafish Locomotor Activity for Developmental Neurotoxicity Screening Bridgett N. Hill, Kayla D. Coldsnow, Deborah L. Hunter, Joan M. Hedge, David Korest, Kimberly A. Jarema, and Stephanie Padilla 16. A Behavioral Test Battery to Assess Larval and Adult Zebrafish after Developmental Neurotoxic Exposure Andrew B. Hawkey, Zade Holloway, and Edward D. Levin 17. Evaluation of Neurotoxic Effects in Zebrafish Embryos by Automatic Measurement of Early Motor Behaviors Elisabet Teixidó, Nils Klüver, Afolarin O. Ogungbemi, Eberhard Küster, and Stefan Scholz 18. Application of Fluorescence Microscopy and Behavioral Assays to Demonstrating Neuronal Connectomes and Neurotransmitter Systems in C. elegans Omamuyovwi M. Ijomone, Priscila Gubert, Comfort O. A. Okoh, Alexandre M. Varão, Leandro de O. Amara, Oritoke M. Aluko, and Michael Aschner Part VI In Vitro Methods 19. Effects of Neurotoxic or Pro-Regenerative Agents on Motor and Sensory Neurite Outgrowth in Spinal Cord Organotypic Slices and DRG Explants in Culture Sara Bolivar, Ilary Allodi, Mireia Herrando, and Esther Udina 20. Integrative In Vitro/Ex Vivo Assessment of Dopaminergic Neurotoxicity in Rodents using Striatal Synaptosomes and Membrane Preparations Raúl López-Arnau and David Pubill 21. Quantification of Oligodendrocytes and Myelin in Human iPSC-Derived 3D Brain Cell Cultures (Brainspheres) David Pamies, Megan Chesnut, Hélène Paschoud, Marie-Gabrielle Zurich, Thomas Hartung, and Helena T. Hogberg 22. Measurement of Electrical Activity of Differentiated Human iPSC-Derived Neurospheres Recorded by Microelectrode Arrays (MEA) Kristina Bartmann, Julia Hartmann, Julia Kapr, and Ellen Fritsche Subject Index List…

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