Overview

Excitatory amino acids (EAAs) as neurotransmitters are the subject of vast and rapidly expanding interest. The First Edition of Excitatory Amino Acids and Synaptic Transmission was the first text to provide anoverview of the function of EAAs in transmission at the synapses and in the organization of the nervous system. The First Edition is a well-respected reference text for neuroscience researchers; it provides a comprehensive account of the physiological, pharmacological, chemical, molecular, biological, and neural networking aspects of the EAAs. The Second Edition has been revised so that its text is even more user-friendly; plus its coverage has been expanded to include the up-to-date approaches of molecular biology and biophysics. The well-praised explanatory glossary has also been improved.

Full Product Details

Author:   Howard V. Wheal (The University of Southampton) ,  Angus W. Thompson (University of Pittsburgh, Pennsylvania, U.S.A.)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Dimensions:   Width: 19.10cm , Height: 2.40cm , Length: 24.80cm
Weight:   0.940kg
ISBN:  

9780127460314

ISBN 10:   0127460314
Pages:   388
Publication Date:   19 October 1995
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Presynaptic Release Mechanisms:<$> D.G. Nicholls,<$> Excitatory Amino Acid Release from Isolated Nerve Terminals. E.F. Stanley,<$> Calcium Entry and the Functional Organization of the Presynaptic Transmitter Release Site. Molecular Pharmacology:<$> A.B. Young, D.G. Standaert, C. Testa, U. Wullner, M. Catania, and J.B. Penny, Jr.,<$> Excitatory Amino Acids Receptor Distribution: Quantitative Autoradiographic Ligand Binding and In Situ<$> Hybridization Studies.P. Krogsgarrd-Larsen, B. Ebert, T.N. Johansen, F. Bischoff, and U. Madsen,<$> Excitatory Amino Acid Antagonists, Partial Agonists, Antagonists, and Modulators: Design and Therapeutic Prospects. B. Lambolez, E. Audinat., and J. Rossier,<$> Study of Glutamate-Gated Channels at the Single Cell Level by Patch Clamp RT PCR. J.A. Saugstad, T.P. Segerson, and G.L. Westbrook,<$> Modulation of Ion Channels and Synaptic Transmission by Matabotropic Glutamate Receptors. Channel Properties:<$> M.L. Mayer, K.M. Partin, D.K. Patneau, L.A. Wong, L. Vyklicky, Jr., M. Benveniste, and D. Bowie,<$> Desensitization at AMPA, Kainate, and NMDA Receptors. J.W. Johnson, S.M. Antonov, T.A. Blanpied, and Y. Li-Smerin,<$> Channel Block of the NMDA Receptor. M.Segal,<$> Imaging of [Ca]<->i<$> in Dendrites and Spines during Responses to NMDA and Synaptic Stimulation in Cultured Hippocampal Neurones. S.G. Cull-Candy, M. Farrant, and D. Feldmeyer,<$> NMDA Channel Conductance: A Users Guide. Synaptic Events and Circuitry:<$> I.D. Forsythe, M. Barnes-Davies, and H.M. Brew,<$> The Calyx of Held: A Model for Transmission at Mammalian Glutamatergic Synapses. A.M. Thomson and J. Deuchars,<$> Diverse Pre- and Post-synaptic Properties of Fast Excitatory Synapses. D. Turner, J. Isaac, Y. Chen, E. Stockley, and H.V. Wheal,<$> Analysis of Dendritic Synaptic Sites in Hippocampal CA1 Pyramidal Cells--Assessment of Variability and Nonuniformity. R. Miles and J.-C. Poncer,<$> Recurrent Excitatory Synapses and Circuits in the CA3 Region of the Hippocampus. S.C. Massey and G. Maguire,<$> The Role of Glutamate in Retinal Circuitry. T.E. Salt and P.L. Herrling,<$> Excitatory Amino Acid Transmitter Function in Mammalian Central Pathways. Synaptic Plasticityand Metabotropic Receptors:<$> R.C. Malenka,<$> Postsynaptic Events Mediating LTP and LTD. W. Singer and A. Artola,<$> The Role of NMDA Receptors in Use-Dependent Synaptic Plasticity of the Visual Cortex. Glossary. References. Subject Index.

Reviews

...takes up the challenge of presenting an extensive overview of this field and, now in its second edition, well reflects its excitement and its rapid changes...The second edition is every bit as useful as the first...This book is appealing most of all because it succeeds in painting a detailed picture of glutamatergic synapses from nearly every available aspect: transitters, receptors, rlaese mechanisms, modulation, and integration. --SCIENCE --SCIENCE

Author Information

For the past 18 years, Dr. Angus Thomson has been involved at the forefront of developments in cellular and molecular immunology as they apply to our further understanding of the immune system and how they can more effectively be regulated to control adverse immune reactions that occur in autoimmune disorders, transplant rejection, and allergy.

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