Overview

Much research since the 1960s and 1970s has shown that the inflammatory response, while critical for host defence during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to this volume may now provide new inroads into the treatment of sepsis.

Full Product Details

Author:   Peter Q. Eichacker ,  Jérôme Pugin
Publisher:   Springer
Imprint:   Springer
Edition:   2001 ed.
Volume:   2
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   0.477kg
ISBN:  

9780792372356

ISBN 10:   0792372352
Pages:   195
Publication Date:   31 December 2000
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1. Sepsis Definitions.- 2. Definitions: Sepsis vs. SIRS.- 3. Toll-like Receptors.- 4. Macrophage Migration Inhibitory Factor (MIF): A Pro-inflammatory Mediator of Sepsis.- 5. Genetic Susceptibility to Infection and Sepsis.- 6. Impact of Genomic Variation on Inflammatory Processes and Sepsis.- 7. Corticosteroids in Sepsis.- 8. The Bidirectional Effect of Inflammation on Bacterial Growth: A New Insight into the Role of Glucocorticoids in the Resolution of Severe Infections.- 9. Anti-Inflammatory Therapy in Sepsis.- 10. Perspectives in Anti-Inflammatory Therapies in Sepsis.- 11. Immunostimulation in Sepsis.- 12. Granulocyte Colony Stimulating Factor as a Therapy for Pneumonia and Sepsis in the Nonneutropenic Host: Preclinical and Clinical Trials.

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