Overview

These volumes cover all relevant aspects of recent research in estrogens and antiestrogens from chemistry, physiology, pharmacology to clinical applications. Particular emphasis is devoted to new developments in the area of estrogen receptors including estrogen receptor b and the mode of action of novel partial estrogen agonists/antagonists. Further topics address the importance of estrogen and anti- estrogens in fertility, aging, cancer, animal husbandry and environment. Part I discusses the complex chemistry of steroidal and non-steroidal estrogens and antiestrogens as well as the molecular mechanisms of estrogen action. Information is provided on the metabolism and the various physiological and pathophysiological responses of estrogens. The chapters have been written by experts in the field of endocrinology for researchers, lecturers, physicians and pharmacologists. Due to their broad scope these volumes will be indispensable reference books in any library.

Full Product Details

Author:   Michael Oettel ,  Ekkehard Schillinger
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   1999 ed.
Volume:   135 / 1
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   0.896kg
ISBN:  

9783540650164

ISBN 10:   3540650164
Pages:   409
Publication Date:   30 July 1999
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

History of Estrogen Research.- 1 History of Estrogen Research.- 1: Chemistry of Estrogens and Antiestrogens.- 2 Steroidal Estrogens.- 3 Non-steroidal Estrogens.- 4 Antiestrogens and Partial Agonists.- 5 Structure — Activity Relationships.- 2: Molecular Biology of Estrogenic Action.- 6 Structure and Function of the Estrogen Receptor.- 7 Estrogen-Regulated Genes.- 8 Regulation of Constitutive and Inducible Nitric Oxide Synthase by Estrogen.- 9 Non-Genomic Effects of Estrogens.- 10 Molecular Mechanisms of Antiestrogen Action.- 3: Biosynthesis and Metabolism of Endogenous Estrogens.- 11 Estrogen Transforming Enzymes.- 12 Metabolism of Endogenous Estrogens.- 4: Physiology and Pathophysiology of Estrogens.- 13 Phylogeny of Estrogen Synthesis, Extragenital Distribution of Estrogen Receptors and Their Development Role.- 14 Female Reproductive Tract.- 15 Estrogen and Brain Function: Implications for Aging and Dementia.- 16 Cardiovascular System.- 17 Immune System.- 18 Male Reproductive function.- 19 The Effect of Estrogens and Antiestrogens on the Urogenital Tract.- 20 Effects of Estrogens on Various Endocrine Regulations.

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