Overview

For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli­ cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro­ gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the ""classic"" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu­ ously hallmark results in reproductive endocrinology worldwide.

Full Product Details

Author:   Michael Oettel ,  Ekkehard Schillinger
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1999
Volume:   135 / 1
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.664kg
ISBN:  

9783642636677

ISBN 10:   3642636675
Pages:   409
Publication Date:   16 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

History of Estrogen Research.- 1 History of Estrogen Research.- 1: Chemistry of Estrogens and Antiestrogens.- 2 Steroidal Estrogens.- 3 Non-steroidal Estrogens.- 4 Antiestrogens and Partial Agonists.- 5 Structure — Activity Relationships.- 2: Molecular Biology of Estrogenic Action.- 6 Structure and Function of the Estrogen Receptor.- 7 Estrogen-Regulated Genes.- 8 Regulation of Constitutive and Inducible Nitric Oxide Synthase by Estrogen.- 9 Non-Genomic Effects of Estrogens.- 10 Molecular Mechanisms of Antiestrogen Action.- 3: Biosynthesis and Metabolism of Endogenous Estrogens.- 11 Estrogen Transforming Enzymes.- 12 Metabolism of Endogenous Estrogens.- 4: Physiology and Pathophysiology of Estrogens.- 13 Phylogeny of Estrogen Synthesis, Extragenital Distribution of Estrogen Receptors and Their Development Role.- 14 Female Reproductive Tract.- 15 Estrogen and Brain Function: Implications for Aging and Dementia.- 16 Cardiovascular System.- 17 Immune System.- 18 Male Reproductive function.- 19 The Effect of Estrogens and Antiestrogens on the Urogenital Tract.- 20 Effects of Estrogens on Various Endocrine Regulations.

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