Overview

Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.

Full Product Details

Author:   Rakesh Kumar Tekade, PhD (Assistant Professor, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research Ahmedabad, Gujarat, India)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Weight:   1.560kg
ISBN:  

9780443158407

ISBN 10:   0443158401
Pages:   752
Publication Date:   22 March 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Understanding Pharmacotoxicology 2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development 3. Omics in Mechanistic and Predictive Toxicology 4. Role of Micro RNAs in Toxicology 5. Exosomes as Mediators of Chemical-Induced Toxicity 6. Types of Cellular Responses to Chemical Toxicants 7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury 8. Role Of “Toxicant-Induced Loss of Tolerance” in the Emergence of Disease 9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction 10. Adverse Outcome Pathway for Chemical Toxicity 11. Toxicokinetics and Organ-Specific Toxicity 12. Dose Selection for Toxicity Studies 13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing 14. Medication Error and its Toxicity Connection 15. Idiosyncratic Toxicity 16. Toxicological Risk Assessment 17. Clinical Detoxification of the Body 18. Principles of Management of Acute Poisoning 19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure 20. Toxicity Labels 21. Toxic Potential Indicator 22. Aquatic Toxicology 23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions 24. Psychopharmacology in Late Life: Key Challenges and Opportunities 25. Regulatory Agencies for Toxicity Studies 26. Key Challenges for Toxicologists in the 21st Century

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Author Information

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

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