Overview

In its extensively revised and updated Second Edition, this book provides a solid foundation for readers interested in clinical research. Discussion encompasses genetic, pharmacoepidemiologic and implementation research. All chapters have been updated with new information and many new tables have been added to elucidate key points. The book now offers discussion on how to handle missing data when analyzing results, and coverage of Adaptive Designs and Effectiveness Designs and new sections on Comparative Effectiveness Research and Pragmatic Trials. Chapter 6 includes new material on Phase 0 Trials, expanded coverage of Futility Trials, a discussion of Medical Device approval, Off Label Drug use and the role of the FDA in regulating advertising. Additional new information includes the role of pill color and shape in association with the placebo effect and an examination of issues surrounding minority recruitment. The final chapter offers a new section on manuscript preparationalong with a discussion of various guidelines being adopted by journals: CONSORT, STROBE, PRISMA, MOOSE and others; and coverage of Conflicts of Interest, Authorship, Coercive Citation, and Disclosures in Industry-Related Associations. Building on the strengths of its predecessor in its comprehensive approach and authoritative advice, the new edition offers more of what has made this book a popular, trusted resource for students and working researchers alike.

Full Product Details

Author:   Stephen P. Glasser
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 2nd ed. 2014
Dimensions:   Width: 15.50cm , Height: 2.40cm , Length: 23.50cm
Weight:   7.022kg
ISBN:  

9783319376837

ISBN 10:   3319376837
Pages:   461
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface 1. The Beginning – Historical Aspects of Clinical Research, Clinical Research: Definitions, “Anatomy and Physiology,” and the Quest for “Universal Truth” Stephen P Glasser   2. Introduction to Clinical Research Concepts, Essential Characteristics of Clinical Research, Overview of Clinical Research Study Designs Stephen P Glasser   3. A Focus on Clinical Trials Stephen P Glasser   4. Alternative Interventional Study Designs Stephen P Glasser 5. Phase 4 (Postmarketing) Research Stephen P Glasser , Elizabeth Delzell, Maribel Salas  6. The Role of the USA Food and Drug Administration in Clinical Research Stephen P Glasser, Carol M. Ashton, Nelda P. Wray  7. The Placebo and Nocebo Effect Stephen P Glasser, William Frishman  8. Recruitment and Retention in Clinical Research Stephen P Glasser   9. Data Safety and Monitoring Boards (DSMBs) Stephen P Glasser MD, O. Dale Williams   10. Meta-analysis, Evidence Based Medicine, and Clinical Guidelines Stephen P Glasser, Sue Duval  11. Research Methods for Genetic Studies Sadeep Shrestha, Donna K Arnett  12. Research Methods for Pharmacoepidemiology Studies Maribel Salas, Bruno Stricker  13. Implementation Research: Beyond the Traditional Randomized Controlled Trial Amanda H. Salanitro, Lauren Powell, Carlos A. Estrada 14. Research Methodology for Studies of Diagnostic Tests Stephen P Glasser 15. Statistical Power & Sample Size: Some Fundamentals For Clinician Researchers J. Michael Oakes  16. Association, Cause, and Correlation Stephen P Glasser, Gary Cutter                 17. Bias, Confounding, and Effect Modification (Interaction) Stephen P Glasser                 18. It’s All About Uncertainty Stephen P Glasser, George Howard   19. Grant and Manuscript Writing Donna K Arnett   20. The Media and Clinical Research Stephen P Glasser MD     21. Mentoring and the Mentee Stephen P Glasser, Edward W Hook III     22. Presentation Skills: How to Present Research Results Stephen P Glasser                                      

Reviews

`Essentials of Clinical Research, 2nd edition' ... offers the student or academic researcher an unusual selection of basic and advanced topics relating to clinical research. ... The book also includes essays on the ancillary but important topics of manuscript and grant writing, mentoring and advising, presentation skills, and, for the blessed/cursed, dealing with the media. (Norman M. Goldfarb, Journal of Clinical Research Best Practices, Vol. 10 (11), November, 2014)

'Essentials of Clinical Research, 2nd edition' ... offers the student or academic researcher an unusual selection of basic and advanced topics relating to clinical research. ... The book also includes essays on the ancillary but important topics of manuscript and grant writing, mentoring and advising, presentation skills, and, for the blessed/cursed, dealing with the media. (Norman M. Goldfarb, Journal of Clinical Research Best Practices, Vol. 10 (11), November, 2014)

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