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Author:   Steven G. Elliott ,  MaryAnn Foote ,  Graham Molineux
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   2nd, revised and extended ed. 2009
Dimensions:   Width: 17.00cm , Height: 2.50cm , Length: 24.40cm
Weight:   0.761kg
ISBN:  

9783764386948

ISBN 10:   3764386940
Pages:   330
Publication Date:   15 April 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Background.- Erythropoiesis: an overview.- Regulation of endogenous erythropoietin production.- Biology of erythropoietin.- Erythropoiesis—genetic abnormalities.- Erythropoiesis-stimulating agents.- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin.- Commercial production of recombinant erythropoietins.- Biosimilar epoetins.- New molecules and formulations.- Erythropoietin receptor.- Structural basis for the signal transduction of erythropoietin.- Intracellular signaling by the erythropoietin receptor.- Mechanism of erythropoietin receptor activation.- Clinical utility.- Pharmacokinetics of erythropoiesis-stimulating agents.- Use of erythropoietic stimulating agents in the setting of renal disease.- Abuse of recombinant erythropoietins and blood products by athletes.- Role and regulation of iron metabolism in erythropoiesis and disease.- Nonhematopoietic effects of erythropoiesis-stimulating agents.

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