Overview

This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia will be covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.

Full Product Details

Author:   Graham Molineux ,  Mary A. Foote ,  Steven Elliott
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   2003 ed.
Dimensions:   Width: 16.50cm , Height: 1.90cm , Length: 24.10cm
Weight:   0.771kg
ISBN:  

9783764369194

ISBN 10:   3764369191
Pages:   280
Publication Date:   July 2003
Audience:   College/higher education ,  Professional and scholarly ,  College/higher education ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

I. Background and basic science * Erythropoiesis: an overview. Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin. Structural basis for the signal transduction of erythropoietin. Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues. Erythropoietin receptor signaling processes. Clinical pharmacokinetic properties of rHuEPO: a review. Biology of erythropoietin. Commercial production of recombinant erythropoietins * II. Clinical use of recombinant erythropoietins * Use of recombinant erythropoietins in the setting of renal disease. Erythropoietic therapy in the practice of oncology. Use of recombinant erythropoietins for the treatment of anemia of chronic disease. Use of erythropoietins in the surgical setting. Abuse of recombinant erythropoietins by athletes. Antibodies to endogenous and recombinant erythropoietin. New molecules and formulations of recombinant human erythropoietin * Glossary of terms and abbreviations * Index.

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