Overview

Epigenetics refers to DNA and chromatin modifications that persist from one cell division to the next despite a lack of change in the underlying DNA sequence. It is an emergent field since its implication in physiological and disease processes is now widely accepted. The effects of epigenetics play an important role in development but can also arise stochastically with ageing. Since their discovery in 1983, cancer-associated epigenetic changes have become accepted as playing a pivotal role in carcinogenesis, in conjunction with classical genomic mutations. Thus it is now well established that an epigenetic mechanism underlies the pathogenesis of cancer and there is evidence implicating epigenetic factors in the pathogenesis of idiopathic mental disorders such as schizophrenia, bipolar disorder and even autism. This new book gathers the latest research from around the globe in this field of study and related topics.

Full Product Details

Author:   Balázs Pintér ,  Zsolt Mészáros
Publisher:   Nova Science Publishers Inc
Imprint:   Nova Science Publishers Inc
Dimensions:   Width: 26.00cm , Height: 2.00cm , Length: 18.00cm
Weight:   0.808kg
ISBN:  

9781607414544

ISBN 10:   1607414546
Pages:   303
Publication Date:   19 May 2010
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Preface; Techniques in Cancer Epigenetics; Melatonin: Epigenetic Mechanisms in Cancer Inhibition; The Epigenetic Re-Programming of Phenotypic Differences in Behavior; Role of H3 Phosphorylation in Different Biological Processes in Normal and Disease States; The Role of DNA Methylation in Colorectal Cancer; Epigenetic Clues to Arthritic Diseases; Evolution of the Fpg/Nei family of DNA Glycosylases; The Clinical and Etiological Relevance of MLH1 Promoter Hypermethylation in Ovarian Tumours; Epigenetic Role in Longevity Echoes Conserved Stress Survival Strategies; Epigenetics and Neurodegeneration: A Connection Overlooked; DNA Methylation Changed by 5-azacytidine Can Affect Normal Fetal and Placental Development; Epigenetic Analysis in Breast Cancer Progression; Cancer Epigenetics; Index.

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