Overview

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.

Full Product Details

Author:   Susan M. Gasser ,  En Li
Publisher:   Birkhauser Verlag AG
Imprint:   Birkhauser Verlag AG
Edition:   2011 ed.
Volume:   67
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.639kg
ISBN:  

9783764389888

ISBN 10:   3764389885
Pages:   270
Publication Date:   02 October 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

DNA Methylation and Cancer.- Genome-wide Epigenetic Modifications in Cancer.- DNA Repair and the Control of DNA Methylation.- Errors in Erasure: Links Between Histone lysine Methylation Removal and Disease.- Histone Modifications in Cancer Biology and Prognosis.- Dynamics of Histone Lysine Methylation: Structures of Methyl Writers and Eraser.- Epigenetic Mechanisms of Mental Retardation.- Histone and DNA Modifications in Mental Retardation.- HDAC Inhibitors and Cancer Therapy.- Epigenetic Mechanisms in Acute Myeloid Leukemia.- The Liver-Specific MicroRNA miR-122: Biology and Therapeutic Potential.- Witold Filipowicz and Helge Großhans.- Transcriptional Regulatory Networks in Embryonic Stem Cells.- Small Molecules in Cellular Reprogramming and Differentiation.

Reviews

Author Information

Tab Content 6

Author Website:  

Countries Available

All regions