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OverviewThe growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail. Full Product DetailsAuthor: Michael Lubbert , Peter A. JonesPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: 2014 ed. Dimensions: Width: 15.50cm , Height: 2.30cm , Length: 23.50cm Weight: 6.878kg ISBN: 9783642384035ISBN 10: 364238403 Pages: 325 Publication Date: 15 January 2014 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsReviewsFrom the reviews: This new book covers the timely topic of epigenetic therapy. ... The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. ... This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy. (Gerd Pfeifer, Doody's Book Reviews, May, 2014) From the reviews: This new book covers the timely topic of epigenetic therapy. ... The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. ... This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy. (Gerd Pfeifer, Doody's Book Reviews, May, 2014) Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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