Overview

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Full Product Details

Author:   Helmtrud I. Roach ,  Felix Bronner ,  Richard O.C. Oreffo
Publisher:   Springer London Ltd
Imprint:   Springer London Ltd
Edition:   2011 ed.
Dimensions:   Width: 19.50cm , Height: 1.50cm , Length: 26.00cm
Weight:   0.760kg
ISBN:  

9781848826434

ISBN 10:   1848826435
Pages:   236
Publication Date:   02 April 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Epigenetics and Chronic Diseases: An Overview.- Techniques to Study DNA Methylation and Histone Modification.- Mechanisms of Epigenetic Gene Silencing.- Mechanisms of Epigenetic Gene Activation in Disease: Dynamics of DNA Methylation and Demethylation.- The Role of Histone Demethylases in Disease.- Autoimmune Diseases.- Epigenetics of Rheumatoid Arthritis.- DNA Methylation Changes in Osteoarthritis.- Epigenetics and Type 2 Diabetes.- Epigenetic Regulation of Asthma and Allergic Diseases.- Epigenetics in Psychiatry.- Epigenetics and Late-Onset Alzheimer’s Disease.- Epigenetic Mechanisms in the Developmental Origins of Adult Disease.- Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease.- Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic Syndrome.

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