Overview

The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.

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9781489985583

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Reviews

From the reviews: This well-illustrated book is an excellent source of cutting-edge scientific information on epigenetic marks such as cytosine methylation and cytosine hydroxymethylation, histone tail modifications, histone variants and nucleosome positional information, recognized to play a fundamental role in cancer development and progression. ... There are very few books available on this subject. This one will be very useful for students and researchers interested in knowing more about epigenetic alterations in oncogenesis. (Omer Iqbal, Doody's Book Reviews, August, 2013)

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