Overview

Enzyme Regulation in Metabolic Pathways shows the reader how to understand the roles of enzymes and their kinetic constants in intermediary metabolism. It provides a means of correlating data obtained in experimental studies to multiple possible mechanisms through which some enzyme may catalyze the conversion of a substrate to a product. Although not the most appropriate means of determining some potential kinetic mechanism, quasi-equilibrium assumptions are used throughout the book, keeping the rate equation derivations simple. Actual metabolic pathways with known (presumed) positive and negative regulation events are linked to these potential kinetic mechanisms using both rate equation derivations and data plots illustrating how the rate equation derivations can be used to explain the data plots.  This book will be a valuable reference for students in biological sciences and biochemistry majors required to take a core course in enzymology.

Full Product Details

Author:   Lloyd Wolfinbarger, Jr. (BioScience Consultants, llc, Norfolk, Virginia, USA)
Publisher:   John Wiley and Sons Ltd
Imprint:   Wiley-Blackwell
Dimensions:   Width: 17.00cm , Height: 1.50cm , Length: 24.90cm
Weight:   0.522kg
ISBN:  

9781119155386

ISBN 10:   111915538
Pages:   184
Publication Date:   31 March 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Preface vii Author’s Review ix Part I 1 Characteristics of Enzymes 3 2 Self-Assembly of Polymers 17 3 Beginnings of Equations 27 4 Metabolite Distribution Systems 37 5 Modification of Enzymatic Activity 51 6 Modification of Metabolite Flow Through Metabolic Pathways 67 7 Which is the Real Substrate? 75 8 Non-Quasi-Equilibrium Assumptions 79 9 Underlying Attributes of Assessing Enzymatic Activities 85 Part II 10 Breakdown of the Michaelis–Menten Equation (or Complex Enzyme Mechanisms) 97 11 Rate Equation Derivation by the King–Altman Method: Two Substrates and Two Products 117 12 Modification of Enzyme Mechanisms: The Next Generation 141 13 What Are These “Rate Constants” We Have Been Dealing With? 151 Index 165

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Lloyd Wolfinbarger, Jr. Professor Emeritus at Old Dominion University in Norfolk, Virginia, USA

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