Overview

"This revised edition takes account of advances in the last five years with regard to the impact of biologically based technologies. With the development in molecular biology, especially in genetic engineering of organisms and in site specific mutagenesis of genes, many problems of fundamental and applied science have been solved, not least in enzymology. Added to these advances the possibility of generating catalysts from antibodies has become a topic of major interest. These major innovations have changed the emphasis of much bioorganic research. Whereas in the past the protein was often the ""sleeping partner"" in a study, its detailed function is now the major focus of scientific interest. This study reveals how, similarly in industry, the potential of genetically manipulated organisms to satisfy the needs for the production of chemicals and foodstuffs has been widely recognized. The scope of the book has been extended to include further discussion of areas of industrial significance in relation to chemical synthesis and the food industry. The chapter on the food industry has a greater applied scientific bias than many of the others and because of the macromolecular nature of the substrates involved is less specific with regard to detailed structural organic chemistry."

Full Product Details

Author:   Colin Suckling
Publisher:   Chapman and Hall
Imprint:   Chapman and Hall
Edition:   2nd ed. 1990
Dimensions:   Width: 15.60cm , Height: 2.20cm , Length: 23.40cm
Weight:   1.620kg
ISBN:  

9780412349706

ISBN 10:   0412349701
Pages:   384
Publication Date:   08 March 1990
Audience:   Professional and scholarly ,  Professional & Vocational
Replaced By:   9780751403626
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Contributors.- Preface.- 1 Infant Enzyme Chemistry.- 2 The Mechanistic Basis of Enzyme Catalysis.- 2.1 The mechanistic approach.- 2.2 Concepts of catalysis.- 2.3 Describing a mechanism.- 2.4 Kinetics: the measure of catalysis.- 2.5 Stereochemistry and specificity.- 2.6 Stereochemistry and mechanism.- 2.7 Entropy and enzymic catalysis.- 2.8 Acid-base catalysis.- 2.9 Linear free-energy relationships and enzymic reactions.- 2.10 Enzymic efficiency.- 2.11 Examples of intramolecular catalysis.- 2.12 Transition state analogues.- 2.13 Multiple binding sites.- 2.14 Biomimetic chemistry.- 2.15 Conclusion.- References.- 3 Chemical Models of Selected Coenzyme Catalyses.- 3.1 Introduction.- 3.2 Model investigations of nicotinamide coenzymes.- 3.3 Flavin catalyses.- 3.4 Catalyses relating to vitamin B1 and analogues.- 3.5 Pyroxidal catalyses.- 3.6 Catalyses of thiol coenzymes.- 3.7 Conclusion.- References.- 4 Selectivity in Synthesis - Chemicals or Enzymes?.- 4.1 Introduction.- 4.2 Problems overcome.- 4.3 Logic and analogy in the synthetic uses of enzymes and micro-organisms.- 4.4 Enzymes and chemical reagents in ‘competition’.- 4.5 Late-stage functional-group modification.- 4.6 Biomimetic chemistry in synthesis.- 4.7 Enzymes in organic solvents.- 4.8 Advances in protein chemistry and molecular biology.- 4.9 Conclusions.- References.- 5 Enzymes As Targets for Drug Design.- 5.1 Introduction.- 5.2 Case studies in drug discovery.- 5.3 Recent developments and their application to inhibitor design.- References.- 6 The Impact of Metal Ion Chemistry on Our Understanding of Enzymes.- 6.1 Introduction and general chemical principles.- 6.2 The transition elements iron and copper.- 6.3 Transition metal ions.- 6.4 Main group elements.- 6.5 Some toxic metals.- 6.6 Metal ions as drugs.- 6.7Modern physical methods.- 6.8 Conclusions 262 References.- 7 The Enzymology of The Biosynthesis of Natural Products.- 7.1 Introduction.- 7.2 Recent advances in the study of biosynthetic enzymes.- 7.3 Terpenoid cyclases.- 7.4 Problems and prospects 298 References.- 8 Enzymes in The Food Industry.- 8.1 Introduction.- 8.2 Amylases and starch hydrolysis.- 8.3 Enzymes acting on glucose and oligosaccharides.- 8.4 The plant cell wall and its breakdown.- 8.5 Industrial applications of plant cell wall degrading enzymes.- 8.6 Exogenous enzymes in cheese making.- 8.7 Conclusions 348.- References.- 9 Enzymology And Protein Chemistry in The Wider Area of Biology.- 9.1 Introduction.- 9.2 Studies of enzymes by techniques of molecular biology.- 9.3 Theoretical treatments of enzyme catalysis.- 9.4 Protein structure, homology and genetic relationships.- 9.5 Interactions between proteins and DNA.- 9.6 Novel catalysts.- 9.7 Apolipoprotein B.- 9.8 Receptors.- 9.9 Conclusions 372.- References.

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