Overview

A normal endometrial cycle is associated with changes in both endometrial glands and stroma that allow the pathologist to diagnose microscopically the phase of menstrual cycle. Irregular menstrual bleeding and menorrhagia occur frequently among perimenopausal women. Any women over the age of 40 years with menorrhagia or other forms of increased vaginal bleeding should undergo endometrial biopsy in order to detect atypical endometrial hyperplasia and endometrial carcinoma. The incidence of malignant neoplasms of the uterus increases rapidly in women over the age of 40 years. In view the high incidence of premalignant and malignant endometrial lesions in perimenopausal patients with abnormal bleeding pattern and a relatively few studies in literature, this study focus on histomorphological spectrum of endometrial changes in perimenopausal abnormal uterine bleeding.

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