Overview

This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections: ·   Evolution and detection of endogenous ADP-ribosylation ·   ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs) ·   ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

Full Product Details

Author:   Friedrich Koch-Nolte
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2015
Volume:   384
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   0.472kg
ISBN:  

9783319345970

ISBN 10:   3319345974
Pages:   213
Publication Date:   23 August 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Part I: Evolution and Detection of Endogenous ADP-Ribosylation   The natural history of ADP-ribosyltransferases and the ADP ribosylation system L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer   Identification and Analysis of ADP-ribosylated Proteins Friedrich Haag and Friedrich Buck   Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)   Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine Klaus Aktories, Gudula Schmidt and Alexander E. Lang   Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein Hideaki Tsuge, Toshiharu Tsurumura   Regulation of nitrogenase by reversible mono-ADP-ribosylation Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo   ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch   Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe   Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)   Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family Ana Filipa Pinto and Herwig Schüler   Function and regulation of the mono-ADP-ribosyltransferase ARTD10 Max Kaufmann, Karla L. H. Feijs, and Bernhard Lüscher   Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15 Maria Di Girolamo

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Friedrich Koch-Nolte is a professor at University Hospital Hamburg-Eppendorf, Institute for Immunology, Hamburg, Germany

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