Overview

Written by a leading expert in the field, this is a comprehensivereview of the methods for preparing stereochemically definedfluorine-containing compounds of biomedical importance. Fluorinated organic compounds are well known for their unusualreactivity but the growing importance of these compounds in thebiomedical field has been accompanied by an increasing awareness ofthe necessity to synthesise and explore the biological propertiesof stereochemically defined fluoro-compounds. This is the firstbook written on this exciting area of research. It contains: * detailed reviews on stereocontrolled synthesis of biologicallyimportant compounds * 21 chapters covering the main areas of asymmetric synthesis andbiocatalysts where fluorine plays a key role * mechanisms and methods for synthesizing fluoro-organiccompounds Written for professionals involved in organic, physical andorganofluorine chemistry, natural product synthesis, biological,pharmaceutical and other life science related industries.

Full Product Details

Author:   Vadim A. Soloshonok (National Research Institute of Nagoya, Japan)
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 16.30cm , Height: 4.20cm , Length: 23.70cm
Weight:   1.106kg
ISBN:  

9780471973720

ISBN 10:   0471973726
Pages:   690
Publication Date:   13 May 1999
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

1. Asymmetric Fluorination 2. Asymmetric of Fluoroalkylation 3. Synthesis of Stereochemically Defined Fluoro-Organic Compoundsvi Dehydroxy-Fluorination and Related Reactions 4. Asymmetric Synthesis of Fluoro-Organic Compounds via ChiralSulfoxide Chemistry 5. Synthesis of Stereochemically Defined Trifluoromethyl-ContainingCompounds from (S)-3,3,3-Trifluoropropene Oxide 6. Asymmetric Reduction of Fluorine-Containing CarbonylCompounds 7. Asymmetric Aldol Reactions of Fluoro-Carbonyl Compounds 8. Asymmetric Michael Addition of Reactions of Fluorocarbons 9. Asymmetric Oxidation of Fluoro-Olefins 10. Biocatalytic Approach to Enantiomerically EnrichedFluoro-Organic Compounds 11. Stereocontrolled Syntheses of Fluorinated Carbohydrates 12. Asymmetric Synthesis of Fluoro-amino acids 13. Chiral non-racemic Fluorinated Nucleosides - Recent Synthetic Methods 14. Asymmetric Syntheses and Resolutions of Fluorinated VolatileAnesthetics 15. Fluorine-Containing Chiral Auxiliaries and Ligands for GeneralAsymmetric Synthesis 16. Fluorine-Containing Agents for Determining Enantiomeric Excessof Chiral Molecules 17. Fluorine-Containing Chiral Liquid Crystals: Syntheses andProperties 18. Synthesis of Enantiopure alpha-Trifluoromethyl Alcohols viaChiral Lewis Acid-Catalyzed Carbonyl-Ene Reactions and theirApplication in the Design of New Liquid Crystals 19. Coordination Ability of Fluorine to Proton or Metals Based onExperimental and Theoretical Evidence 20. Physical and Structural Size of Fluorine in Fluoro-OrganicCompounds 21. The Chemical and Physiological Size of Fluorine

Reviews

It is clearly the view of the editor and authors who have contributed to this volume that organofluorine chemistry is at a new threshold with an array of methods now available to place fluorine and fluorinated functional groups at stereogenic centres. Such compounds have hardly been exploited commercially. The wealth of information in this book demonstrates this focus which one anticipates will have an increasing impact on the fine chemical, pharmaceuticals and agrochemicals sectors. The book is packed with examples from the recent literature and the readers' attention is continually drawn to points of detail and anecdotes as the volume is browsed. This is not just a book for specialists in organo-fluorine chemistry, it is a book for all organic chemists. ... This is a splendid book., (David O'Hagan, Natural Products Reports)

-It is clearly the view of the editor and authors who have contributed to this volume that organofluorine chemistry is at a new threshold with an array of methods now available to place fluorine and fluorinated functional groups at stereogenic centres. Such compounds have hardly been exploited commercially. The wealth of information in this book demonstrates this focus which one anticipates will have an increasing impact on the fine chemical, pharmaceuticals and agrochemicals sectors. The book is packed with examples from the recent literature and the readers' attention is continually drawn to points of detail and anecdotes as the volume is browsed. This is not just a book for specialists in organo-fluorine chemistry, it is a book for all organic chemists. ... This is a splendid book.-, (David O'Hagan, Natural Products Reports)

Author Information

Vadim A. Soloshonok is the editor of Enantiocontrolled Synthesis of Fluoro-Organic Compounds: Stereochemical Challenges and Biomedical Targets, published by Wiley.

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