Overview

A Readily Applicable Framework for Novel Drug Design It is only 20 years since the reach of genetic knowledge has allowed for the development of protein biotherapeutics, but in that time the pace has been fast. While the literature abounds, the field has lacked a comprehensive accounting of this progress. Emerging Protein Biotherapeutics consolidates current knowledge of key protein targets important in autoimmunity and cancers, exploring basic aspects and diverse clinical application. Presents Strategies to Exploit Therapeutic Uses In this volume, leading researchers cover many aspects of biology related to protein targets, ranging from the in vivo role in the disease process, to various strategies exploiting development of these targets for therapeutic use. Each chapter includes background, a discussion of clinical implications, an account of preclinical and clinical testing of various candidates, and a listing of key references. This volume makes the study of protein biotherapeutics accessible at all levels of expertise. It offers an efficient and rational way to grasp the theoretical and experimental knowledge currently available while also providing a deeper understanding of disease processes. Most importantly, it presents a framework that can be readily employed by those looking to develop their own strategies in pursuit of new clinical applications.

Full Product Details

Author:   Iqbal S. Grewal (Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA) ,  Iqbal S. Grewal (Preclinical Therapeutics, Seattle Genetics, Inc., Bothell, Washington, USA) ,  Daniel Remick (Boston University, Massachusetts, USA) ,  John C. Byrd
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 15.60cm , Height: 2.50cm , Length: 23.40cm
Weight:   0.682kg
ISBN:  

9781420063202

ISBN 10:   1420063200
Pages:   368
Publication Date:   26 June 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

INTRODUCTION. Overview of Antibody-Based Therapeutics: Present and Future Promise. BIOLOGICS FOR AUTOIMMUNITY AND INFLAMMATION. Biologic Therapies for Multiple Sclerosis. Biologic Therapies in Rheumatoid Arthritis. Biologic Therapies in Systemic Lupus Erythematosus. Biologic Therapies for Inflammatory Bowel Disease. Biologic Therapies for Psoriasis. TNFa Inhibitors: Emerging Biologic Therapies for the Treatment of Asthma. Protein-Based Therapies in Experimental and Clinical Transplantation. Biologic Therapies for Type 1 Diabetes. BIOLOGICS FOR HEMATOLOGICAL MALIGNANCIES. Biologic Therapies for Acute Myeloid Leukemia/Myelodysplastic Syndrome. Biologic Therapies for Non-Hodgkin Lymphoma and Hodgkin Disease. Biologic Therapies for Chronic Lymphocytic Leukemia. Biologic Therapies for Multiple Myeloma and Plasma Cell Disorders. DEVELOPMENT OF BIOTHERAPIES FOR SOLID TUMORS. Antibody-Based Therapies for Carcinomas. Role of Vascular Targeting Agents in the Treatment of Solid Tumors: Current and Future Developments. Recent Advancements in the Use of Antibody–Drug Conjugates for Cancer Therapy. INDEX.

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Author Information

Iqbal S. Grewal, Ph.D., is a well-established scientist and biotechnologist with many years of research in immunology and oncology. He has extensive experience in the discovery and development of innovative protein-based biotherapeutics in many disease areas. Some of Dr. Grewal’s findings have already helped to translate research into key drug candidates for the treatment of autoimmune diseases and cancers. Currently, he is serving as Vice President of Preclinical Therapeutics at Seattle Genetics and leading preclinical research for the development of monoclonal antibodies and antibody-drug conjugates as therapeutics in the areas of autoimmunity and oncology.

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