Overview

Since the first implant of a carbon microelectrode in a rat 35 years ago, there have been substantial advances in the sensitivity, selectivity and temporal resolution of electrochemical techniques. Today, these methods provide neurochemical information that is not accessible by other means. The growing recognition of the versatility of electrochemical techniques indicates a need for a greater understanding of the scientific foundation and use of these powerful tools. Electrochemical Methods for Neuroscience provides an updated summary of the current, albeit evolving, state of the art and lays the scientific foundation for incorporating electrochemical techniques into on-going or newly emerging research programs in the neuroscience disciplines. With contributions from pioneers in the field, the text outlines the applications and benefits of a wide range of electrochemical techniques. It explores the methodology behind the acquisition of neurochemical and neurobiological data through continuous amperometry, fast scan cyclic voltammetry, high-speed chronoamperometry, ion-selective microelectrodes, enzyme based microelectrodes, and in vivo voltammetry with telemetry. The text also introduces emerging concepts in the field such as the correlation of electrochemical recordings with information obtained from patch clamp, electrophysiological, and behavioral techniques. By presenting up-to-date information on the growing collection of electrochemical methods, microsensors, and research techniques, Electrochemical Methods for Neuroscience assists seasoned researchers and newcomers to the field in making sound decisions about adopting the most appropriate of these tools for their future research objectives.

Full Product Details

Author:   Adrian C. Michael ,  Laura Borland ,  Laura Borland (Booz Allen Hamilton, Inc., Joppa, Maryland, USA) ,  Nancy R. Zahniser
Publisher:   Taylor & Francis Inc
Imprint:   CRC Press Inc
Dimensions:   Width: 17.80cm , Height: 3.50cm , Length: 25.40cm
Weight:   1.111kg
ISBN:  

9780849340758

ISBN 10:   0849340756
Pages:   544
Publication Date:   13 December 2006
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction to Electrochemical Methods in Neuroscience, Rapid Dopamine Release in Freely Moving Rats, Presynaptic Regulation of Extracellular Dopamine as Studied by Continuous Amperometry in Anesthetized Animals, Fast Scan Cyclic Voltammetry of Dopamine and Serotonin in Mouse Brain Slices, High-Speed Chronoamperometry to Study Kinetics and Mechanisms for Serotonin Clearance in vivo, Using High-Speed Chronoamperometry Coupled with Local Dopamine Application to Assess Dopamine Transporter Function, Determining Serotonin and Dopamine Uptake Rates in Synaptosomes Using High-Speed Chronoamperometry, Using Fast-Scan Cyclic Voltammetry to Investigate Somatodendritic Dopamine Release, From Interferant Anion to Neuromodulator: Ascorbate Oxidizes Its Way to Respectability, Biophysical Properties of Brain Extracellular Space Explored with Ion-Selective Microelectrodes, Integrative Optical Imaging and Related Techniques, Hydrogen Peroxide as a Diffusible Messenger: Evidence from Voltammetric Studies of Dopamine Release in Brain Slices, In Vivo Voltammetry with Telemetry, Oxidative Stress at the Single Cell Level, Electrochemistry at the Cell Membrane/Solution Interface, The Patch Amperometry Technique: Design of a Method to Study Exocytosis of Single Vesicles, Amperometric Detection of Dopamine Exocytosis from Synaptic Terminals, Scanning Electrochemical Microscopy as a Tool in Neuroscience, Principles, Development and Applications of Self-Referencing Electrochemical Microelectrodes to the Determination of Fluxes at Cell Membranes, Second-by-Second Measures of L-Glutamate and Other Neurotransmitters Using Enzyme-Based Microelectrode Arrays, Telemetry for Biosensor Systems, The Principles, Development and Application of Microelectrodes for the in vivo Determination of Nitric Oxide, In vivo Fast-scan Cyclic Voltammetry of Dopamine near Microdialysis Probes

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Adrian C. Michael, Laura Borland

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