Overview

This dissertation, Effects of Postnatal Interference of Vestibular GABA Transmission on Navigation Behavior in Adult Rats by Zher Wen, Au, 歐哲彣, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Although spatial navigation is predominantly guided by allothetic visual cues, idiothetic cues can obtain control when familiar visual cues are not available. In path integration, the current position and orientation are estimated and continuously updated using idiothetic cues, which are contributed by the vestibular system. Previous studies have revealed that vestibular lesioned rats were significantly impaired in path integration. Rats assessed in the current study received neonatal treatment with either VU0240551 (KCC2 blocker) or muscimol (GABAA receptors agonist) in the vestibular nuclei. Path integration ability appears to be intact in rats receiving either treatment. However, VU0240551-treated rats displayed impairments in their ability to resolve conflicting allothetic and idiothetic cues. Therefore, it is proposed that the ability to properly resolve a cue-conflict requires the normal polarity of GABA and/or glycine action in the vestibular nuclei during the neonatal period. DOI: 10.5353/th_b5319513 Subjects: Spatial behavior in animals

Full Product Details

9781361352137

Table of Contents

Reviews

Author Information

Tab Content 6

Countries Available