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Author:   Stephen M. King (Professor, Department of Molecular Biology and Biophysics Director, Electron Microscopy Facility, University of Connecticut Health Center)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Weight:   1.560kg
ISBN:  

9780128094716

ISBN 10:   0128094710
Pages:   684
Publication Date:   22 November 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

I. History and Evolution 1. Discovery of dynein and its properties: a personal account 2. Origins of cytoplasmic dynein 3. The evolutionary biology of dyneins II. Dyneins in Ciliary Biology 4. Cytoplasmic preassembly and trafficking of axonemal dyneins 5. Composition and assembly of axonemal dyneins 6. Organization of dyneins in the axoneme 7. Genetic approaches to axonemal dynein function in Chlamydomonas and other organisms 8. Regulatory mechanics of outer arm dynein motors 9. Control of axonemal inner dynein arms 10. Ciliary and flagellar motility and the nexin-dynein regulatory complex 11. Regulation of dynein-driven ciliary and flagellar movement 12. Dynein-mediated photobehavioral responses in Chlamydomonas 13. Dynein and intraflagellar transport III. Cytoplasmic Dynein Biology 14. Cytoplasmic dynein function defined by subunit composition 15. Regulation of cytoplasmic dynein motility 16. Insights into cytoplasmic dynein function and regulation from fungal genetics 17. Role of dynactin in dynein-mediated motility 18. Role of cytoplasmic dynein and dynactin in mitotic checkpoint silencing 19. Cytoplasmic dynein during mitosis 20. Dynein and dynactin at microtubule plus ends 21. Drosophila cytoplasmic dynein: mutations, tools and developmental functions

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Author Information

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

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