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Author:   Stephen M. King (Professor, Department of Molecular Biology and Biophysics Director, Electron Microscopy Facility, University of Connecticut Health Center)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Edition:   2nd edition
Weight:   1.290kg
ISBN:  

9780128094709

ISBN 10:   0128094702
Pages:   530
Publication Date:   28 November 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

I. Structure and Mechanics of Dynein Motors 1. Electron microscopy of isolated dynein complexes and the power stroke mechanism 2. Mechanism and regulation of dynein motors 3. Structural analysis of dynein intermediate and light chains 4. Biochemical purification of axonemal and cytoplasmic dyneins 5. Single molecule dynein motor mechanics in vitro 6. Biophysical properties of dynein in vivo 7. Mechanics of bidirectional cargo transport 8. Chemical probes for dynein 9. Computational modeling of dynein activity and the generation of flagellar beating waveforms II. Dynein Dysfunction and Disease 10. Impacts of virus-mediated manipulation of host dynein 11. Use of mouse genetics to probe cytoplasmic dynein function 12. Cytoplasmic dynein and its regulators in neocortical development and disease 13. Cytoplasmic dynein dysfunction and neurodegenerative disease 14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies 15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins 16. Ciliary dynein dysfunction as a consequence of chronic alcohol exposure 17. Dynein-based motility of pathogenic protozoa 18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder 19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice?

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Author Information

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

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