Overview

This book has been arranged such that any analytical chemist can start analytical experiments for a drug or poison in a crude biological matrix, even if she/he has no experience of analyzing that compound. This is particularly useful in view of the acute risk of terrorist attacks in the world today.Special care has been given to clarify the origins (manufacturers) or synthetic methods for chemicals to be used to reproduce the experiments.The specimens to be analyzed are presumed to be complicated matrices (not clean waste or ground water) such as whole blood, tissues or urine, which contain cells, membranes, proteins and lipids in every chapter. Therefore, procedures for extraction of a drug or poison have been given in great detail. Each chapter is composed of a rigid internal structure comprising Introduction, Reagents and their Preparation, Conditions of Analytical Instruments, Procedures, Assessment of the Methods, Poisoning Case Examples, Toxic and Lethal Concentrations in Human Specimens, Notes and References.The chapters have been written by 67 authors who are experts engaged in analysis of each compound.This type of book for analysis of drugs and poisons has not been published elsewhere in the world.

Full Product Details

Author:   Osamu Suzuki ,  Kanako Watanabe
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2005 ed.
Dimensions:   Width: 15.50cm , Height: 4.30cm , Length: 23.50cm
Weight:   1.325kg
ISBN:  

9783540222774

ISBN 10:   3540222774
Pages:   672
Publication Date:   02 May 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Chapters of general nature 1) How to handle biological specimens 2) Alternative specimens 3) Pitfalls and cautions in analysis of drugs and poisons 4) Pretreatments of human specimens 5) Detection methods 6) A computer system for diagnosis of causative drugs and poisons developed by the Japan Poison Information Center (Tokyo) 7) Practical use of the poison-net developed by the Japan Poison Information Network (Hiroshima) 8) Problems in toxin analysis in emergency medicine 9) Analyses of chemical weapons and their related compounds Chapters on specific toxins 1. Volatile compounds 1) Carbon monoxide 2) Hydrogen sulfide and its metabolites 3) Cyanide 4) Methanol and formic acid 5) Ethanol 6) Chloroform and dichloromethane 7) Toluene, benzene, xylene and stylene 8) Alkyl nitrites 9) Compenents of gasoline and kerosene 2. Controlled drugs 1) Amphetamines and their metabolites 2) Cannabinoids and their metabolites 3) Morphine and its analogues 4) Cocaine and its metabolites 5) Pentazocine 6) Lysergic acid diethylamide (LSD) 7) 3,4-Methylenedioxyamphetamines 8) Phencyclidine 9) ?- Hydroxybutyric acid 3. Psychopharmaceuticals and hypnotics 1) Phenothiazines 2) Butyrophenones 3) Tricyclic and tetracyclic antidepressants 4) Benzodiazepines 5) Bromisovalum 6) Barbiturates 4. General drugs 1) Diphenylmethane antihistaminics 2) Propionic acid derivative analgesic-antipyretics 3) Acetaminophen (paracetamol) 4) Acetylsalicylic acid 5) Antiepileptics 6) Muscle relaxants 7) ss- Blockers 8) Local anaesthetics 9) Salicylicacid 10) ss- Lactam antibiotics 5. Chemicals of daily necessaries 1) Hypochlorite 2) Benzalkonium chlorides 3) Hair dyes 4) Permethrin 5) Boric acid 6) Naphthalene 7) p-Dichlorobenzene 8) Ethylene glycol 6. Natural toxins and alkaloids 1) Aconite toxins 2) Mushroom toxins 3) Tetrodotoxin 4) Methylxanthine derivatives 5) Nicotine and cotinine 6) Tropane alkaloids 7) Oleander toxins 7. Pesticides 1) Simultaneous analysis of pesticides by GC/MS 2) Organophosphorus pesticides 3) Glufosinate and glyphosate 4) Carbamate pesticides 5) Paraquat and diquat 6) Cresol 7) Diazine and triazine herbicides 8) Coumarin rodenticides 8. Miscellaneous 1) Sarin and its decomposition products 2) VX and its decomposition products 3) Sodium azide 4) Arsenic compounds and other inorganic poisons 5) Nitrate and nitrite compounds 6) Methemoglobin

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