Overview

This work furnishes interdisciplinary perspectives on drug transport and transport-associated resistance from the clinical, biochemical and physicochemical points of view. It focuses on specific antibacterial, antifungal and antiparasitic, and anticancer agents, and provides up-to-date reviews on topics such as antibiotic transport in mycobacteria, transport of azole antifungals, glutathione S-conjugate efflux pump, and more.

Full Product Details

Author:   Nafsika H. Georgopapadakou
Publisher:   Taylor & Francis Inc
Imprint:   Marcel Dekker Inc
Volume:   17
Dimensions:   Width: 21.60cm , Height: 3.70cm , Length: 27.90cm
Weight:   1.043kg
ISBN:  

9780824793999

ISBN 10:   0824793994
Pages:   664
Publication Date:   22 June 1995
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Out of Stock Indefinitely
Availability:   Awaiting stock  

Table of Contents

Clinical Significance of Antibacterial Transport; The Impact of Transport-Associated Resistance in Anticancer Chemotherapy; Composition and Properties of Cellular Membranes; Mechanisms of Drug Transport in Prokaryotes and Eukaryotes; Beta-LactamPermeation; Aminoglycoside Transport; Tetracycline Uptake and Efflux in Bacteria; Quinolone Uptake and Efflux Antibiotic Transport in Mycobacteria; Bacterial Transport as an Import Mechanism and Target for Antimicrobials; Internalization of Amphotericin Band Other Polyene Antifungals in Mammalian Cells - A Possible Origin of Their Toxicity; Azole Antifungals; Chloroquine Transport in the Malarial Parasite Plasmodium falciparum; Transport of Antifolates and Antimonials in Drug-Resistant Leishmania;Nucleoside Transport; Mechanisms of Receptor-Mediated Folate and Antifolate Membrane Transport in Cancer Chemotherapy; Cellular and Biochemical Aspects of Multidrug Resistance; Modulation of Multidrug Resistance in Tumor Cells; Glutathione Conjugation andATP-Dependent Export of Anticancer Drugs; Circumventing Transport-Associated Resistance Through Drug Delivery.

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