Overview

This reference/text examines the importance of toxicokinetics on drug disposition and outlines its practical applications in drug development - helping readers incorporate the most up-to-date findings into their own work. Consolidating research from international authorities in the fields of toxicology, pharmacokinetics, metabolism and biochemistry to illustrate the interdisciplinary nature of toxicokinetic situations, Drug Toxicokinetics : covers regulatory guidelines for conducting toxicokinetic studies to obtain maximum information for safety assessment and clinical use of drug candidates; illustrates the principles of linear and nonlinear pharmacokinetics and compares them to toxicokinetics; displays relationships between the time-span of drug concentrations in the body and the appearance of toxic effects; and spotlights problems and solutions regarding metabolism impact in toxicology as well as the bioactivation of drugs. Containing over 950 literature citations, figures and tables, Drug Toxicokinetics is intended as a reference for pharmacists; organic and medicinal chemists; industrial, academic and government pharmacologists and toxicologists; pharmacokineticists; safety-evaluation scientists; pathologists and biochemists. It should also be a useful guide for personnel in public health, risk assessment, chemical industry, drug metabolism and drug regulatory affairs as well as for clinical and preclinical drug development scientists. The book should also serve as a useful text for upper-level undergraduate and graduate students in these disciplines.

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9780824790196

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