Overview

Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced. This publication will be of immense value not only to allergologists, dermatologists and anyone prescribing medication, but also to scientists in a pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases. (A Karger """"Publishing Highlights 1890–2015"""" title.)

Full Product Details

Author:   W.J. Pichler
Publisher:   S Karger AG
Imprint:   S Karger AG
Dimensions:   Width: 19.30cm , Height: 2.30cm , Length: 26.20cm
Weight:   1.260kg
ISBN:  

9783805582698

ISBN 10:   3805582692
Pages:   438
Publication Date:   31 May 2007
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Awaiting stock  
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Table of Contents

Foreword; Epidemiology of Drug Allergies; Epidemiology and Causes of Drug Hypersensitivity: Demoly, P.; Viola, M.; Rebelo Gomes, E.; Romano, A.; Epidemiology and Causes of Severe Cutaneous Adverse Reactions to Drugs: Mockenhaupt, M.; Pathomechanisms, Genetics and Animal Models; Chemical-Induced Contact Hypersensitivity in the: Mouse Model: Martin, S.F.; Lessons from Nickel Hypersensitivity: Structural Findings: Weltzien, H.U.; Drugs as Haptens, Antigens and Immunogens: Park, B.K.; Sanderson, J.P.; Naisbitt, D.J.; The p-i Concept: Evidence and Implications: Gerber, B.O.; Pichler, W.J.; Tolerance Mechanisms to Small Molecular Compounds: Cavani, A.; De Pita, O.; HIV and Drug Hypersensitivity: Pirmohamed, M.; Abacavir Hypersensitivity: Nolan, D.; Almeida, C.-A.; Phillips, E.; Mallal, S.; Genetics of Severe Drug Hypersensitivity Reactions in Han Chinese: Hung, S.-I.; Chung, W.-H.; Chen, Y.-T.; Nevirapine Hypersensitivity: Shenton, J.M.; Popovic, M.; Uetrecht, J.P.; Animal Models of Toxic Epidermal Necrolysis: Azukizawa, H.; Itami, S.; Non-Clinical Testing Approaches for Drug Development: Possibilities and Limitations: Kawabata, T.T.; Piccotti, J.R.; Adverse Side Effects to Biological Agents: Pichler, W.J.; Campi, P.; Clinical Manifestations; Drug Hypersensitivity Reactions: Classification and Relationship to T-Cell Activation: Pichler, W.J.; Urticaria and Anaphylaxis due to Betalactams (Penicillins and Cephalosporins): Torres, M.J.; Mayorga, C.; Blanca, M.; Perioperative Anaphylaxis: Dewachter, P.; IgE-Mediated Allergy to Pyrazolones, Quinolones and Other Non-[beta]-Lactam Antibiotics: Campi, P.; Manfredi, M.; Severino, M.; Hypersensitivity Reactions to Iodinated Contrast Media: An Update: Christiansen, C.; Maculopapular Drug Eruptions: Yawalkar, N.; Drug-Induced Hypersensitivity Syndrome and Viral Reactivation: Shiohara, T.; Takahashi, R.; Kano, Y.; Clinic and Pathogenesis of Severe Bullous Skin Reactions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis: Allanore, L.; Roujeau, J.-C.; Drug Allergic Liver Injury: Cerny, A.; Bertoli, R.; Drug-Induced Interstitial Nephritis: Keller, M.; Spanou, Z.; Pichler, W.J.; Blood Dyscrasias Caused by Hypersensitivity to Drugs: Aster, R.H.; Allergy and Pseudoallergy to Drugs and Vaccines in Children: Ponvert, C.; Hadj-Rabia, S.; Scheinmann, P.; Hypersensitivity to Aspirin and Other NSAIDs: Mechanisms, Clinical Presentation and Management: Szczeklik, A.; Nizankowska-Mogilnicka, E.; Sanak, M.; Diagnosis; Approach to the Patient with a Drug Hypersensitivity Reaction - Clinical Perspectives: Bircher, A.J.; Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions: Barbaud, A.; In vitro Tests of T-Cell-Mediated Drug Hypersensitivity: Beeler, A.; Pichler, W.J.; In vitro Tests: Basophil Activation Tests: Sanz, M.L.; Gamboa, P.M.; De Weck, A.L.; Desensitization; Desensitization with Antibiotics: Solensky, R.; Drug Desensitization in Oncology: Chemotherapy Agents and Monoclonal Antibodies: Castells, M.; Author Index; Subject Index.

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